Genetic Loci Associated with Allergic Sensitization in Lithuanians

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dc.contributor.author Sauliene, Ingrida
dc.contributor.author Greiciuviene, Jurate
dc.contributor.author Sukiene, Laura
dc.contributor.author Juskeviciute, Neringa
dc.contributor.author Benner, Christian
dc.contributor.author Zinkeviciene, Aukse
dc.contributor.author Ripatti, Samuli
dc.contributor.author Donner, Kati
dc.contributor.author Kainov, Denis
dc.date.accessioned 2016-03-03T13:15:02Z
dc.date.available 2016-03-03T13:15:02Z
dc.date.issued 2015-07-27
dc.identifier.citation Sauliene , I , Greiciuviene , J , Sukiene , L , Juskeviciute , N , Benner , C , Zinkeviciene , A , Ripatti , S , Donner , K & Kainov , D 2015 , ' Genetic Loci Associated with Allergic Sensitization in Lithuanians ' , PLoS One , vol. 10 , no. 7 , 0134188 . https://doi.org/10.1371/journal.pone.0134188
dc.identifier.other PURE: 52856937
dc.identifier.other PURE UUID: 5af00fde-8ee2-4943-a3d9-91fde2c20631
dc.identifier.other WOS: 000358594300059
dc.identifier.other Scopus: 84941710696
dc.identifier.uri http://hdl.handle.net/10138/160425
dc.description.abstract Allergic rhinitis (AR) is a common and complex disease. It is associated with environmental as well as genetic factors. Three recent genome-wide association studies (GWAS) reported altogether 47 single nucleotide polymorphisms (SNPs) associated with AR or allergic sensitization (AS) in Europeans and North Americans. Two follow up studies in Swedish and Chinese replicated 15 associations. In these studies individuals were selected based on the self-reported AR, or AR/AS diagnosed using blood IgE test or skin prick test (SPT), which were performed often without restriction to specific allergens. Here we performed third replication study in Lithuanians. We used SPT and carefully selected set of allergens prevalent in Lithuania, as well as Illumina Core Exome chip for SNP detection. We genotyped 270 SPT-positive individuals (137 Betulaceae -, 174 Poaceae-, 199 Artemisia-, 70 Helianthus-, 22 Alternaria-, 22 Cladosporium-, 140 mites-, 95 cat-and 97 dog dander-sensitive cases) and 162 SPT-negative controls. We found altogether 13 known SNPs associated with AS (p en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GENOME-WIDE ASSOCIATION
dc.subject RHINITIS
dc.subject ASTHMA
dc.subject METAANALYSIS
dc.subject POPULATION
dc.subject REPLICATION
dc.subject PREVALENCE
dc.subject 3111 Biomedicine
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Genetic Loci Associated with Allergic Sensitization in Lithuanians en
dc.type Article
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Clinicum
dc.contributor.organization Samuli Olli Ripatti / Principal Investigator
dc.contributor.organization Department of Public Health
dc.contributor.organization Denis Kainov / Principal Investigator
dc.contributor.organization Biostatistics Helsinki
dc.contributor.organization Complex Disease Genetics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1371/journal.pone.0134188
dc.relation.issn 1932-6203
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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