B-Cell Responses to Human Bocaviruses 1-4 : New Insights from a Childhood Follow-Up Study

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Kantola , K , Hedman , L , Tanner , L , Simell , V , Makinen , M , Partanen , J , Sadeghi , M , Veijola , R , Knip , M , Ilonen , J , Hyoty , H , Toppari , J , Simell , O , Hedman , K & Soderlund-Venermo , M 2015 , ' B-Cell Responses to Human Bocaviruses 1-4 : New Insights from a Childhood Follow-Up Study ' , PLoS One , vol. 10 , no. 9 , 0139096 . https://doi.org/10.1371/journal.pone.0139096

Title: B-Cell Responses to Human Bocaviruses 1-4 : New Insights from a Childhood Follow-Up Study
Author: Kantola, Kalle; Hedman, Lea; Tanner, Laura; Simell, Ville; Makinen, Marjaana; Partanen, Juulia; Sadeghi, Mohammad; Veijola, Riitta; Knip, Mikael; Ilonen, Jorma; Hyoty, Heikki; Toppari, Jorma; Simell, Olli; Hedman, Klaus; Soderlund-Venermo, Maria
Contributor: University of Helsinki, Department of Virology
University of Helsinki, Department of Virology
University of Helsinki, Department of Virology
University of Helsinki, Medicum
University of Helsinki, University of Helsinki
University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2015-09-29
Language: eng
Number of pages: 12
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/160538
Abstract: Human bocaviruses (HBoVs) 1-4 are recently discovered, antigenically similar parvoviruses. We examined the hypothesis that the antigenic similarity of these viruses could give rise to clinically and diagnostically important immunological interactions. IgG and IgM EIAs as well as qPCR were used to study similar to 2000 sera collected from infancy to early adolescence at 3-6-month intervals from 109 children whose symptoms were recorded. We found that HBoV1-4-specific seroprevalences at age 6 years were 80%, 48%, 10%, and 0%, respectively. HBoV1 infections resulted in significantly weaker IgG responses among children who had pre-existing HBoV2 IgG, and vice versa. Furthermore, we documented a complete absence of virus type-specific immune responses in six viremic children who had pre-existing IgG for another bocavirus, indicating that not all HBoV infections can be diagnosed serologically. Our results strongly indicate that interactions between consecutive HBoV infections affect HBoV immunity via a phenomenon called "original antigenic sin", cross-protection, or both; however, without evident clinical consequences but with important ramifications for the serodiagnosis of HBoV infections. Serological data is likely to underestimate human exposure to these viruses.
Subject: ANTIBODY-DEPENDENT ENHANCEMENT
ORIGINAL ANTIGENIC SIN
DENGUE VIRUS-INFECTION
INFLUENZA-A VIRUSES
ACUTE GASTROENTERITIS
LINE U937
CHILDREN
DISEASE
RISK
ASSOCIATION
3111 Biomedicine
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