Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models

Show full item record



Permalink

http://hdl.handle.net/10138/160539

Citation

Berglund , M , Adiels , M , Taskinen , M-R , Boren , J & Wennberg , B 2015 , ' Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models ' , PLoS One , vol. 10 , no. 9 , 0138538 . https://doi.org/10.1371/journal.pone.0138538

Title: Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models
Author: Berglund, Martin; Adiels, Martin; Taskinen, Marja-Riitta; Boren, Jan; Wennberg, Bernt
Contributor: University of Helsinki, Research Programs Unit
Date: 2015-09-30
Language: eng
Number of pages: 16
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/160539
Abstract: Context Mathematical models may help the analysis of biological systems by providing estimates of otherwise un-measurable quantities such as concentrations and fluxes. The variability in such systems makes it difficult to translate individual characteristics to group behavior. Mixed effects models offer a tool to simultaneously assess individual and population behavior from experimental data. Lipoproteins and plasma lipids are key mediators for cardiovascular disease in metabolic disorders such as diabetes mellitus type 2. By the use of mathematical models and tracer experiments fluxes and production rates of lipoproteins may be estimated. Results We developed a mixed effects model to study lipoprotein kinetics in a data set of 15 healthy individuals and 15 patients with type 2 diabetes. We compare the traditional and the mixed effects approach in terms of group estimates at various sample and data set sizes. Conclusion We conclude that the mixed effects approach provided better estimates using the full data set as well as with both sparse and truncated data sets. Sample size estimates showed that to compare lipoprotein secretion the mixed effects approach needed almost half the sample size as the traditional method.
Subject: POPULATION PHARMACOKINETIC PARAMETERS
APOLIPOPROTEIN-B METABOLISM
MULTICOMPARTMENTAL MODEL
DIABETIC DYSLIPIDEMIA
TRIGLYCERIDE KINETICS
VLDL
OVERPRODUCTION
SUBFRACTIONS
DRIVEN
3121 Internal medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
journal.pone.0138538.PDF 795.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record