Diabetes, glucose tolerance, and the risk of sudden cardiac death

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Eranti , A , Kerola , T , Aro , A L , Tikkanen , J T , Rissanen , H A , Anttonen , O , Junttila , M J , Knekt , P & Huikuri , H V 2016 , ' Diabetes, glucose tolerance, and the risk of sudden cardiac death ' , BMC Cardiovascular Disorders , vol. 16 , 51 . https://doi.org/10.1186/s12872-016-0231-5

Title: Diabetes, glucose tolerance, and the risk of sudden cardiac death
Author: Eranti, Antti; Kerola, Tuomas; Aro, Aapo L.; Tikkanen, Jani T.; Rissanen, Harri A.; Anttonen, Olli; Junttila, M. Juhani; Knekt, Paul; Huikuri, Heikki V.
Contributor organization: Clinicum
Department of Medicine
Kardiologian yksikkö
Date: 2016-02-24
Language: eng
Number of pages: 8
Belongs to series: BMC Cardiovascular Disorders
ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-016-0231-5
URI: http://hdl.handle.net/10138/160819
Abstract: Background: Diabetes predisposes to sudden cardiac death (SCD). However, it is uncertain whether greater proportion of cardiac deaths are sudden among diabetes patients than other subjects. It is also unclear whether the risk of SCD is pronounced already early in the course of the disease. The relationship of impaired glucose tolerance (IGT) and SCD is scarcely documented. Methods: A general population cohort of 10594 middle-aged subjects (mean age 44 years, 52.6 % male, follow-up duration 35-41 years) was divided into diabetes patients (n = 82), subjects with IGT (n = 3806, plasma glucose = 9.58 mmol/l in one-hour glucose tolerance test), and controls (n = 6706). Results: Diabetes patients had an increased risk of SCD after adjustment confounders (hazard ratio 2.62, 95 % confidence interval 1.46-4.70, p = 0.001) but risk for non-sudden cardiac death was similarly increased and the proportion of SCD of cardiac deaths was not increased. The SCD risk persisted after exclusion of subjects with baseline cardiac disease or non-fatal cardiac events during the follow-up. Subjects with IGT were at increased risk for SCD (univariate hazard ratio 1.51; 95 % confidence interval 1.31-1.74; p <0.001) and also for non-sudden cardiac deaths and non-fatal cardiac events but adjustments for other risk factors attenuated these effects. Conclusions: Diabetes was associated with increased risk of SCD but also the risk of non-sudden cardiac death was similarly increased. The proportion of cardiac deaths being sudden in subjects with diabetes was not increased. The higher SCD risk in diabetes patients was independent of known cardiac disease at baseline or occurrence of nonfatal cardiac event during the follow-up.
Subject: Death
Diabetes mellitus
Diabetic cardiomyopathies
Prediabetic state
Prospective studies
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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