Reduced beta-cell function in early preclinical type 1 diabetes

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Koskinen , M K , Helminen , O , Matomaki , J , Aspholm , S , Mykkanen , J , Makinen , M , Simell , V , Vaha-Makila , M , Simell , T , Ilonen , J , Knip , M , Veijola , R , Toppari , J & Simell , O 2016 , ' Reduced beta-cell function in early preclinical type 1 diabetes ' , European Journal of Endocrinology , vol. 174 , no. 3 , pp. 251-259 .

Title: Reduced beta-cell function in early preclinical type 1 diabetes
Author: Koskinen, Maarit K.; Helminen, Olli; Matomaki, Jaakko; Aspholm, Susanna; Mykkanen, Juha; Makinen, Marjaana; Simell, Ville; Vaha-Makila, Mari; Simell, Tuula; Ilonen, Jorma; Knip, Mikael; Veijola, Riitta; Toppari, Jorma; Simell, Olli
Contributor organization: Clinicum
Mikael Knip / Principal Investigator
Children's Hospital
Lastentautien yksikkö
Diabetes and Obesity Research Program
HUS Children and Adolescents
Date: 2016-03
Language: eng
Number of pages: 9
Belongs to series: European Journal of Endocrinology
ISSN: 0804-4643
Abstract: Objective: We aimed to characterize insulin responses to i.v. glucose during the preclinical period of type 1 diabetes starting from the emergence of islet autoimmunity. Design and methods: A large population-based cohort of children with HLA-conferred susceptibility to type 1 diabetes was observed from birth. During regular follow-up visits islet autoantibodies were analysed. We compared markers of glucose metabolism in sequential intravenous glucose tolerance tests between 210 children who were positive for multiple (>= 2) islet autoantibodies and progressed to type 1 diabetes (progressors) and 192 children testing positive for classical islet-cell antibodies only and remained healthy (non-progressors). Results: In the progressors, the first phase insulin response (FPIR) was decreased as early as 4-6 years before the diagnosis when compared to the non-progressors (P=0.001). The difference in FPIR between the progressors and non-progressors was significant (P Conclusions: FPIR is decreased several years before the diagnosis of type 1 diabetes, implying an intrinsic defect in beta-cell mass and/or function.
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion

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