New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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Lu , Y , Day , F R , Gustafsson , S , Buchkovich , M L , Na , J , Bataille , V , Cousminer , D L , Dastani , Z , Drong , A W , Esko , T , Evans , D M , Falchi , M , Feitosa , M F , Ferreira , T , Hedman , A K , Haring , R , Hysi , P G , Iles , M M , Justice , A E , Kanoni , S , Lagou , V , Li , R , Li , X , Locke , A , Lu , C , Magi , R , Perry , J R B , Pers , T H , Qi , Q , Sanna , M , Schmidt , E M , Scott , W R , Shungin , D , Teumer , A , Vinkhuyzen , A A E , Walker , R W , Westra , H-J , Zhang , M , Zhang , W , Zhao , J H , Zhu , Z , Afzal , U , Ahluwalia , T S , Bakker , S J L , Bellis , C , Bonnefond , A , Borodulin , K , Buchman , A S , Cederholm , T , Choh , A C , Choi , H J , Curran , J E , de Groot , L C P G M , De Jager , P L , Dhonukshe-Rutten , R A M , Enneman , A W , Eury , E , Evans , D S , Forsen , T , Friedrich , N , Fumeron , F , Garcia , M E , Gartner , S , Han , B-G , Havulinna , A S , Hayward , C , Hernandez , D , Hillege , H , Ittermann , T , Kent , J W , Kolcic , I , Laatikainen , T , Lahti , J , Leach , I M , Lee , C G , Lee , J-Y , Liu , T , Liu , Y , Lobbens , S , Loh , M , Lyytikainen , L-P , Medina-Gomez , C , Michaelsson , K , Nalls , M A , Nielson , C M , Oozageer , L , Pascoe , L , Paternoster , L , Polasek , O , Ripatti , S , Sarzynski , M A , Shin , C S , Narancic , N S , Spira , D , Srikanth , P , Steinhagen-Thiessen , E , Sung , Y J , Swart , K M A , Taittonen , L , Tanaka , T , Tikkanen , E , van der Velde , N , van Schoor , N M , Verweij , N , Wright , A F , Yu , L , Zmuda , J M , Pellikka , N , Forrester , T , Grarup , N , Jackson , A U , Kristiansson , K , Kuulasmaa , T , Kuusisto , J , Lichtner , P , Luan , J , Mahajan , A , Mannisto , S , Palmer , C D , Ried , J S , Scott , R A , Stancakova , A , Wagner , P J , Demirkan , A , Doring , A , Gudnason , V , Kiel , D P , Kuhnel , B , Mangino , M , Mcknight , B , Menni , C , O'Connell , J R , Oostra , B A , Shuldiner , A R , Song , K , Vandenput , L , van Duijn , C M , Vollenweider , P , White , C C , Boehnke , M , Boettcher , Y , Cooper , R S , Forouhi , N G , Gieger , C , Grallert , H , Hingorani , A , Jorgensen , T , Jousilahti , P , Kivimaki , M , Kumari , M , Laakso , M , Langenberg , C , Linneberg , A , Luke , A , Mckenzie , C A , Palotie , A , Pedersen , O , Peters , A , Strauch , K , Tayo , B O , Wareham , N J , Bennett , D A , Bertram , L , Blangero , J , Bluher , M , Bouchard , C , Campbell , H , Cho , N H , Cummings , S R , Czerwinski , S A , Demuth , I , Eckardt , R , Eriksson , J G , Ferrucci , L , Franco , O H , Froguel , P , Gansevoort , R T , Hansen , T , Harris , T B , Hastie , N , Heliovaara , M , Hofman , A , Jordan , J M , Jula , A , Kahonen , M , Kajantie , E , Knekt , P B , Koskinen , S , Kovacs , P , Lehtimaki , T , Lind , L , Liu , Y , Orwoll , E S , Osmond , C , Perola , M , Perusse , L , Raitakari , O T , Rankinen , T , Rao , D C , Rice , T K , Rivadeneira , F , Rudan , I , Salomaa , V , Sorensen , T I A , Stumvoll , M , Tonjes , A , Towne , B , Tranah , G J , Tremblay , A , Uitterlinden , A G , van der Harst , P , Vartiainen , E , Viikari , J S , Vitart , V , Vohl , M-C , Volzke , H , Walker , M , Wallaschofski , H , Wild , S , Wilson , J F , Yengo , L , Bishop , D T , Borecki , I B , Chambers , J C , Cupples , L A , Dehghan , A , Deloukas , P , Fatemifar , G , Fox , C , Furey , T S , Franke , L , Han , J , Hunter , D J , Karjalainen , J , Karpe , F , Kaplan , R C , Kooner , J S , McCarthy , M I , Murabito , J M , Morris , A P , Bishop , J A N , North , K E , Ohlsson , C , Ong , K K , Prokopenko , I , Richards , J B , Schadt , E E , Spector , T D , Widen , E , Willer , C J , Yang , J , Ingelsson , E , Mohlke , K L , Hirschhorn , J N , Pospisilik , J A , Zillikens , M C , Lindgren , C , Kilpelainen , T O & Loos , R J F 2016 , ' New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ' , Nature Communications , vol. 7 , 10495 . https://doi.org/10.1038/ncomms10495

Title: New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Author: Lu, Yingchang; Day, Felix R.; Gustafsson, Stefan; Buchkovich, Martin L.; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L.; Dastani, Zari; Drong, Alexander W.; Esko, Tonu; Evans, David M.; Falchi, Mario; Feitosa, Mary F.; Ferreira, Teresa; Hedman, Asa K.; Haring, Robin; Hysi, Pirro G.; Iles, Mark M.; Justice, Anne E.; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; Lu, Chen; Magi, Reedik; Perry, John R. B.; Pers, Tune H.; Qi, Qibin; Sanna, Marianna; Schmidt, Ellen M.; Scott, William R.; Shungin, Dmitry; Teumer, Alexander; Vinkhuyzen, Anna A. E.; Walker, Ryan W.; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Jing Hua; Zhu, Zhihong; Afzal, Uzma; Ahluwalia, Tarunveer Singh; Bakker, Stephan J. L.; Bellis, Claire; Bonnefond, Amelie; Borodulin, Katja; Buchman, Aron S.; Cederholm, Tommy; Choh, Audrey C.; Choi, Hyung Jin; Curran, Joanne E.; de Groot, Lisette C. P. G. M.; De Jager, Philip L.; Dhonukshe-Rutten, Rosalie A. M.; Enneman, Anke W.; Eury, Elodie; Evans, Daniel S.; Forsen, Tom; Friedrich, Nele; Fumeron, Frederic; Garcia, Melissa E.; Gartner, Simone; Han, Bok-Ghee; Havulinna, Aki S.; Hayward, Caroline; Hernandez, Dena; Hillege, Hans; Ittermann, Till; Kent, Jack W.; Kolcic, Ivana; Laatikainen, Tiina; Lahti, Jari; Leach, Irene Mateo; Lee, Christine G.; Lee, Jong-Young; Liu, Tian; Liu, Youfang; Lobbens, Stephane; Loh, Marie; Lyytikainen, Leo-Pekka; Medina-Gomez, Carolina; Michaelsson, Karl; Nalls, Mike A.; Nielson, Carrie M.; Oozageer, Laticia; Pascoe, Laura; Paternoster, Lavinia; Polasek, Ozren; Ripatti, Samuli; Sarzynski, Mark A.; Shin, Chan Soo; Narancic, Nina Smolej; Spira, Dominik; Srikanth, Priya; Steinhagen-Thiessen, Elisabeth; Sung, Yun Ju; Swart, Karin M. A.; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, Nathalie; van Schoor, Natasja M.; Verweij, Niek; Wright, Alan F.; Yu, Lei; Zmuda, Joseph M.; Pellikka, Niina; Forrester, Terrence; Grarup, Niels; Jackson, Anne U.; Kristiansson, Kati; Kuulasmaa, Teemu; Kuusisto, Johanna; Lichtner, Peter; Luan, Jian'an; Mahajan, Anubha; Mannisto, Satu; Palmer, Cameron D.; Ried, Janina S.; Scott, Robert A.; Stancakova, Alena; Wagner, Peter J.; Demirkan, Ayse; Doring, Angela; Gudnason, Vilmundur; Kiel, Douglas P.; Kuhnel, Brigitte; Mangino, Massimo; Mcknight, Barbara; Menni, Cristina; O'Connell, Jeffrey R.; Oostra, Ben A.; Shuldiner, Alan R.; Song, Kijoung; Vandenput, Liesbeth; van Duijn, Cornelia M.; Vollenweider, Peter; White, Charles C.; Boehnke, Michael; Boettcher, Yvonne; Cooper, Richard S.; Forouhi, Nita G.; Gieger, Christian; Grallert, Harald; Hingorani, Aroon; Jorgensen, Torben; Jousilahti, Pekka; Kivimaki, Mika; Kumari, Meena; Laakso, Markku; Langenberg, Claudia; Linneberg, Allan; Luke, Amy; Mckenzie, Colin A.; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstantin; Tayo, Bamidele O.; Wareham, Nicholas J.; Bennett, David A.; Bertram, Lars; Blangero, John; Bluher, Matthias; Bouchard, Claude; Campbell, Harry; Cho, Nam H.; Cummings, Steven R.; Czerwinski, Stefan A.; Demuth, Ilja; Eckardt, Rahel; Eriksson, Johan G.; Ferrucci, Luigi; Franco, Oscar H.; Froguel, Philippe; Gansevoort, Ron T.; Hansen, Torben; Harris, Tamara B.; Hastie, Nicholas; Heliovaara, Markku; Hofman, Albert; Jordan, Joanne M.; Jula, Antti; Kahonen, Mika; Kajantie, Eero; Knekt, Paul B.; Koskinen, Seppo; Kovacs, Peter; Lehtimaki, Terho; Lind, Lars; Liu, Yongmei; Orwoll, Eric S.; Osmond, Clive; Perola, Markus; Perusse, Louis; Raitakari, Olli T.; Rankinen, Tuomo; Rao, D. C.; Rice, Treva K.; Rivadeneira, Fernando; Rudan, Igor; Salomaa, Veikko; Sorensen, Thorkild I. A.; Stumvoll, Michael; Tonjes, Anke; Towne, Bradford; Tranah, Gregory J.; Tremblay, Angelo; Uitterlinden, Andre G.; van der Harst, Pim; Vartiainen, Erkki; Viikari, Jorma S.; Vitart, Veronique; Vohl, Marie-Claude; Volzke, Henry; Walker, Mark; Wallaschofski, Henri; Wild, Sarah; Wilson, James F.; Yengo, Loic; Bishop, D. Timothy; Borecki, Ingrid B.; Chambers, John C.; Cupples, L. Adrienne; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghazaleh; Fox, Caroline; Furey, Terrence S.; Franke, Lude; Han, Jiali; Hunter, David J.; Karjalainen, Juha; Karpe, Fredrik; Kaplan, Robert C.; Kooner, Jaspal S.; McCarthy, Mark I.; Murabito, Joanne M.; Morris, Andrew P.; Bishop, Julia A. N.; North, Kari E.; Ohlsson, Claes; Ong, Ken K.; Prokopenko, Inga; Richards, J. Brent; Schadt, Eric E.; Spector, Tim D.; Widen, Elisabeth; Willer, Cristen J.; Yang, Jian; Ingelsson, Erik; Mohlke, Karen L.; Hirschhorn, Joel N.; Pospisilik, John Andrew; Zillikens, M. Carola; Lindgren, Cecilia; Kilpelainen, Tuomas Oskari; Loos, Ruth J. F.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Behavioural Sciences
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, University College London
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
University of Helsinki, Children's Hospital
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2016-02
Language: eng
Number of pages: 15
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/160839
Abstract: To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Subject: GENOME-WIDE ASSOCIATION
MASS INDEX
INSULIN-RESISTANCE
COMMON VARIANTS
GENETIC ARCHITECTURE
SUSCEPTIBILITY LOCI
IDENTIFIES COMMON
PROVIDES INSIGHTS
ENERGY-BALANCE
CUTANEOUS NEVI
3121 General medicine, internal medicine and other clinical medicine
515 Psychology
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