Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children

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http://hdl.handle.net/10138/161012

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Korpela , K , Salonen , A , Virta , L J , Kekkonen , R A , Forslund , K , Bork , P & de Vos , W M 2016 , ' Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children ' , Nature Communications , vol. 7 , 10410 . https://doi.org/10.1038/ncomms10410

Title: Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children
Author: Korpela, Katri; Salonen, Anne; Virta, Lauri J.; Kekkonen, Riina A.; Forslund, Kristoffer; Bork, Peer; de Vos, Willem M.
Contributor organization: Research Programs Unit
Department of Bacteriology and Immunology
Medicum
Immunobiology Research Program
Willem Meindert Vos de / Principal Investigator
Veterinary Biosciences
Veterinary Microbiology and Epidemiology
de Vos & Salonen group
Date: 2016-01
Language: eng
Number of pages: 8
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/ncomms10410
URI: http://hdl.handle.net/10138/161012
Abstract: Early-life antibiotic use is associated with increased risk for metabolic and immunological diseases, and mouse studies indicate a causal role of the disrupted microbiome. However, little is known about the impacts of antibiotics on the developing microbiome of children. Here we use phylogenetics, metagenomics and individual antibiotic purchase records to show that macrolide use in 2-7 year-old Finnish children (N = 142; sampled at two time points) is associated with a long-lasting shift in microbiota composition and metabolism. The shift includes depletion of Actinobacteria, increase in Bacteroidetes and Proteobacteria, decrease in bile-salt hydrolase and increase in macrolide resistance. Furthermore, macrolide use in early life is associated with increased risk of asthma and predisposes to antibiotic-associated weight gain. Overweight and asthmatic children have distinct microbiota compositions. Penicillins leave a weaker mark on the microbiota than macrolides. Our results support the idea that, without compromising clinical practice, the impact on the intestinal microbiota should be considered when prescribing antibiotics.
Subject: LACTOBACILLUS-RHAMNOSUS GG
INFANT GUT MICROBIOTA
REAL-TIME PCR
INCREASED RISK
RESPONSES
ASTHMA
OVERWEIGHT
COUNTRIES
EXPOSURE
COHORT
3111 Biomedicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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