C1 domain-targeted isophthalates as protein kinase C modulators : structure-based design, structure-activity relationships and biological activities

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Talman , V , Provenzani , R , af Gennäs , G B , Tuominen , R K & Yli-Kauhaluoma , J 2014 , ' C1 domain-targeted isophthalates as protein kinase C modulators : structure-based design, structure-activity relationships and biological activities ' , Biochemical Society Transactions , vol. 42 , no. 6 , pp. 1543-1549 . https://doi.org/10.1042/BST20140181

Title: C1 domain-targeted isophthalates as protein kinase C modulators : structure-based design, structure-activity relationships and biological activities
Author: Talman, Virpi; Provenzani, Riccardo; af Gennäs, Gustav Boije; Tuominen, Raimo K.; Yli-Kauhaluoma, Jari
Contributor organization: Faculty of Pharmacy
Drug Discovery
Division of Pharmaceutical Chemistry and Technology
Division of Pharmacology and Pharmacotherapy
Date: 2014-12
Language: eng
Number of pages: 7
Belongs to series: Biochemical Society Transactions
ISSN: 0300-5127
DOI: https://doi.org/10.1042/BST20140181
URI: http://hdl.handle.net/10138/161059
Subject: Alzheimer's disease
antiproliferative
C1 domain
cancer
isophthalate
neurite growth protein kinase C
CONFORMATIONALLY CONSTRAINED ANALOGS
DIACYLGLYCEROL DAG
PHORBOL ESTER
PKC-ALPHA
NEUROBLASTOMA-CELLS
CATALYTIC DOMAIN
SH-SY5Y CELLS
BINDING
PHOSPHORYLATION
ACTIVATION
317 Pharmacy
Peer reviewed: Yes
Usage restriction: restrictedAccess


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