SALSA : A Regulator of the early Steps of Complement Activation on Mucosal Surfaces

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Reichhardt , M P & Meri , S 2016 , ' SALSA : A Regulator of the early Steps of Complement Activation on Mucosal Surfaces ' , Frontiers in Immunology , vol. 7 , 85 . https://doi.org/10.3389/fimmu.2016.00085

Title: SALSA : A Regulator of the early Steps of Complement Activation on Mucosal Surfaces
Author: Reichhardt, Martin Parnov; Meri, Seppo
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Medicum
Date: 2016-03-08
Language: eng
Number of pages: 7
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/161079
Abstract: Complement is present mainly in blood. However, following mechanical damage or inflammation, serous exudates enter the mucosal surfaces. Here, the complement proteins interact with other endogenous molecules to keep microbes from entering the parenteral tissues. One of the mucosal proteins known to interact with the early complement components of both the classical and the lectin pathway is the salivary scavenger and agglutinin (SALSA). SALSA is also known as deleted in malignant brain tumors 1 and gp340. It is found both attached to the epithelium and secreted into the surrounding fluids of most mucosal surfaces. SALSA has been shown to bind directly to C1q, mannose-binding lectin, and the ficolins. Through these interactions SALSA regulates activation of the complement system. In addition, SALSA interacts with surfactant proteins A and D, secretory IgA, and lactoferrin. Ulcerative colitis and Crohn's disease are examples of diseases, where complement activation in mucosal tissues may occur. This review describes the latest advances in our understanding of how the early complement components interact with the SALSA molecule. Furthermore, we discuss how these interactions may affect disease propagation on mucosal surfaces in immunological and inflammatory diseases.
Subject: gp340
DMBT1
Crohn's disease
ficolins
MBL
C1q
ulcerative colitis
IBD
INFLAMMATORY-BOWEL-DISEASE
MALIGNANT BRAIN-TUMORS
BOVINE-MILK LACTOFERRIN
INNATE IMMUNE PROTEINS
SALIVARY AGGLUTININ
SCAVENGER RECEPTOR
CROHNS-DISEASE
STREPTOCOCCUS-MUTANS
BACTERIAL RECOGNITION
LECTIN PATHWAY
3111 Biomedicine
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