Diminished salivary epidermal growth factor secretion : a link between Sjogren's syndrome and autoimmune gastritis?

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http://hdl.handle.net/10138/161147

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Koskenpato , K , Ainola , M , Przybyla , B , Kouri , V-P , Virkki , L , Koskenpato , J , Ristimaki , A & Konttinen , Y T 2016 , ' Diminished salivary epidermal growth factor secretion : a link between Sjogren's syndrome and autoimmune gastritis? ' , Scandinavian Journal of Rheumatology , vol. 45 , no. 2 , pp. 118-121 . https://doi.org/10.3109/03009742.2015.1072243

Title: Diminished salivary epidermal growth factor secretion : a link between Sjogren's syndrome and autoimmune gastritis?
Author: Koskenpato, K.; Ainola, M.; Przybyla, B.; Kouri, V-P; Virkki, L.; Koskenpato, J.; Ristimaki, A.; Konttinen, Y. T.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Medicine
University of Helsinki, Medicum
University of Helsinki, Clinicum
Date: 2016-03-03
Language: eng
Number of pages: 4
Belongs to series: Scandinavian Journal of Rheumatology
ISSN: 0300-9742
URI: http://hdl.handle.net/10138/161147
Abstract: Objectives: Healthy human labial salivary glands produce epidermal growth factor (EGF). In Sjogren's syndrome (SS), EGF staining is diminished. SS is also associated with chronic autoimmune corpus gastritis. We therefore hypothesized that EGF secretion would be diminished in SS and that this could affect gastric target cells.Methods: Salivary EGF secretion in SS was compared to that in healthy controls using an enzyme-linked immunosorbent assay (ELISA). EGF receptor (EGFR) immunoreactive cells in the gastric corpus of healthy human subjects were analysed using immunostaining.Results: Salivary secretion of EGF was diminished in SS patients (232.4, range 52.6-618.4, vs. 756.6, range 105.3-1631.6 pg/min, p=0.002). Proton-pump positive parietal cells were mostly EGFR immunoreactive whereas very few pepsinogen I (PGI)-positive cells were EGFR positive.Conclusions: As EGF is relatively acid resistant, salivary gland-derived EGF might participate in an exo/endocrine mode of parietal cell maintenance in the gastric corpus. Deficiency of salivary gland-derived EGF in SS patients may cause impairment of gastric parietal cells resulting in exposure of immunogenic cryptic antigens and loss of immunological self-tolerance.
Subject: PERNICIOUS-ANEMIA
FACTOR RECEPTOR
FACTOR-ALPHA
RELEASE
GLANDS
MUCOSA
3121 General medicine, internal medicine and other clinical medicine
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