Location of metastases in cancer of unknown primary are not random and signal familial clustering

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http://hdl.handle.net/10138/161148

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Hemminki , K , Sundquist , K , Sundquist , J , Hemminki , A & Ji , J 2016 , ' Location of metastases in cancer of unknown primary are not random and signal familial clustering ' , Scientific Reports , vol. 6 , 22891 . https://doi.org/10.1038/srep22891

Title: Location of metastases in cancer of unknown primary are not random and signal familial clustering
Author: Hemminki, Kari; Sundquist, Kristina; Sundquist, Jan; Hemminki, Akseli; Ji, Jianguang
Contributor organization: Clinicum
Medicum
Department of Oncology
Department of Pathology
Transplantation Laboratory
Date: 2016-03-09
Language: eng
Number of pages: 8
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep22891
URI: http://hdl.handle.net/10138/161148
Abstract: Cancer of unknown primary (CUP) is a fatal disease diagnosed through metastases. It shows intriguing familial clustering with certain defined primary cancers. Here we examine whether metastatic location in CUP patients is related to primary non-CUP cancers in relatives based on the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for CUP patients defined by metastatic location depending on cancer in their first degree relatives. SIRs for CUP were high in association with liver (3.94), ovarian (3.41), lung (2.43) and colorectal cancers (1.83) in relatives. The SIR was 1.63 for CUP with metastases in the abdomen when a relative was diagnosed with ovarian cancer. CUP with liver metastases associated with liver (1.44) cancer in relatives. CUP with head and neck region metastases associated with relatives' esophageal (2.87) cancer. CUP metastases in the thorax associated with a relative's cancers in the upper aerodigestive tract (2.14) and lung (1.74). The findings, matching metastatic location in CUP and primary cancer in relatives, could be reconciled if these cases of CUP constitute a phenotypically modified primary lacking tissue identification, resulting from epitope immunoediting. Alternatively, CUP metastases arise in a genetically favored tissue environment (soil) promoting growth of both primary cancers and metastases (seeds).
Subject: POPULATION-BASED ANALYSIS
PRIMARY SITE
PRIMARY ORIGIN
TIME TRENDS
SURVIVAL
CARCINOMA
DIAGNOSIS
HISTOLOGY
PATTERNS
DEATH
3122 Cancers
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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