Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues

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http://hdl.handle.net/10138/161203

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Rasila , T , Lehtonen , A , Kanerva , K , Mäkitie , L T , Haglund , C & Andersson , L C 2016 , ' Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues ' , PLoS One , vol. 11 , no. 3 , 0151175 . https://doi.org/10.1371/journal.pone.0151175

Title: Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues
Author: Rasila, Tiina; Lehtonen, Alexandra; Kanerva, Kristiina; Mäkitie, Laura T.; Haglund, Caj; Andersson, Leif C.
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Department of Pathology
University of Helsinki, Clinicum
University of Helsinki, Medicum
Date: 2016-03-10
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/161203
Abstract: Ornithine decarboxylase (ODC) antizyme inhibitor 2 (AZIN2), originally called ODCp, is a regulator of polyamine synthesis that we originally identified and cloned. High expression of ODCp mRNA was found in brain and testis. We reported that AZIN2 is involved in regulation of cellular vesicle transport and/or secretion, but the ultimate physiological role(s) of AZIN2 is still poorly understood. In this study we used a peptide antibody (K3) to human AZIN2 and by immunohistochemistry mapped its expression in various normal tissues. We found high expression in the nervous system, in type 2 pneumocytes in the lung, in megakaryocytes, in gastric parietal cells co-localized with H, K-ATPase beta subunit, in selected enteroendocrine cells, in acinar cells of sweat glands, in podocytes, in macula densa cells and epithelium of collecting ducts in the kidney. The high expression of AZIN2 in various cells with secretory or vesicle transport activity indicates that the polyamine metabolism regulated by AZIN2 is more significantly involved in these events than previously appreciated.
Subject: INTRACELLULAR VESICLE TRAFFICKING
ORNITHINE-DECARBOXYLASE PARALOGUE
ALZHEIMERS-DISEASE
POLYAMINES
REGULATORS
GENE
3111 Biomedicine
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