Long-term outcome after cerebral venous thrombosis : analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients

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Hiltunen , S , Putaala , J , Haapaniemi , E & Tatlisumak , T 2016 , ' Long-term outcome after cerebral venous thrombosis : analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients ' , Journal of Neurology , vol. 263 , no. 3 , pp. 477-484 . https://doi.org/10.1007/s00415-015-7996-9

Title: Long-term outcome after cerebral venous thrombosis : analysis of functional and vocational outcome, residual symptoms, and adverse events in 161 patients
Author: Hiltunen, Sini; Putaala, Jukka; Haapaniemi, Elena; Tatlisumak, Turgut
Contributor: University of Helsinki, Clinicum
University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences
University of Helsinki, Clinicum
Date: 2016-03
Language: eng
Number of pages: 8
Belongs to series: Journal of Neurology
ISSN: 0340-5354
URI: http://hdl.handle.net/10138/161272
Abstract: Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified consecutive adult CVT patients treated at the Helsinki University Hospital (1987-2013) and invited them to a follow-up visit. Each clinical examination was combined with interview. We also recorded recurrent venous thromboembolism (VTE) and hemorrhagic events during follow-up and antithrombotic medication use. A modified Rankin Scale (mRS) served to assess functional outcome. Logistic regression served to identify independent factors associated with unemployment and functional recovery. Of the 195 patients identified, 21 died, 9 declined to participate, and 4 were excluded from the study. Thus, 161 patients (106 women) underwent an examination after a median of 39 months (interquartile range 14-95). VTE (one of which was CVT) occurred in 9 (6 %) patients, and severe hemorrhagic events in 10 (6 %). Functional outcome was good, with 84 % scoring 0-1 on the mRS; 42 % reported residual symptoms. Altogether, 91 (57 %) patients were employed. After adjusting for age and sex, a National Institutes of Health Stroke Scale score > 2 at admission and low education level, associated with both unfavorable functional outcome and unemployment. Long-term functional outcome after CVT may appear good if measured with mRS, but patients often have residual symptoms and are frequently unable to return to their previous work.
Subject: Cerebral venous thrombosis
Sinus thrombosis
Long-term outcome
Anticoagulation
Follow-up
Vocational status
DURAL SINUS THROMBOSIS
YOUNG-WOMEN
FOLLOW-UP
RECURRENCE
PROGNOSIS
VEIN
RECANALIZATION
RISK
3112 Neurosciences
3124 Neurology and psychiatry
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