Clinicopathological characteristics and cell cycle proteins as potential prognostic factors in myoepithelial carcinoma of salivary glands

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Passador-Santos , F , Gronroos , M , Irish , J , Gilbert , R , Gullane , P , Perez-Ordonez , B , Makitie , A & Leivo , I 2016 , ' Clinicopathological characteristics and cell cycle proteins as potential prognostic factors in myoepithelial carcinoma of salivary glands ' Virchows Archiv , vol. 468 , no. 3 , pp. 305-312 . DOI: 10.1007/s00428-015-1889-2

Title: Clinicopathological characteristics and cell cycle proteins as potential prognostic factors in myoepithelial carcinoma of salivary glands
Author: Passador-Santos, F.; Gronroos, M.; Irish, J.; Gilbert, R.; Gullane, P.; Perez-Ordonez, B.; Makitie, A.; Leivo, I.
Contributor: University of Helsinki, Department of Pathology
University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, Department of Pathology
Date: 2016-03
Number of pages: 8
Belongs to series: Virchows Archiv
ISSN: 0945-6317
URI: http://hdl.handle.net/10138/161382
Abstract: Myoepithelial carcinoma (MCA) is a rare malignancy of salivary glands that was included in the WHO Classification of Head and Neck Tumors in 1991. MCA has shown a broad spectrum of clinical outcomes, but attempts to identify prognostic markers for this malignancy have not resulted in significant progress. Conventional histopathological characteristics such as tumour grade, nuclear atypia, mitotic index and cell proliferation have failed to predict the outcome of MCA. In this study, we reviewed the histopathology of 19 cases of MCA focusing on nuclear atypia, mitotic count, tumour necrosis, nerve and vascular invasion and occurrence of a pre-existing pleomorphic adenoma in connection to the MCA. Histopathological characteristics and clinical information were correlated with the immunohistochemical expression of cell cycle proteins including c-Myc, p21, Cdk4 and Cyclin D3. The proportion of tumour cells immunoreactive for these markers and their intensity of staining were correlated with clinical information using logistic regression, Kaplan-Meier and Cox regression. Using logistic regression analysis, cytoplasmic c-Myc expression was associated with the occurrence of metastases (P = 0.019), but limitations of semi-quantitation of immunostaining and the limited number of cases preclude definitive conclusions. Our data show that the occurrence of tumour necrosis predicts poor disease-free survival in MCA (P = 0.035).
Subject: Myoepithelial carcinoma
Salivary gland
Cell cycle proteins
Immunohistochemistry
Head and neck cancer
MALIGNANT MYOEPITHELIOMA
EXPRESSION
NECROSIS
FEATURES
CANCER
TUMORS
NECK
HEAD
MYC
3111 Biomedicine
3122 Cancers
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