Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

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Fan , Q , Verhoeven , V J M , Wojciechowski , R , Barathi , V A , Hysi , P G , Guggenheim , J A , Hoehn , R , Vitart , V , Khawaja , A P , Yamashiro , K , Hosseini , S M , Lehtimaki , T , Lu , Y , Haller , T , Xie , J , Delcourt , C , Pirastu , M , Wedenoja , J , Gharahkhani , P , Venturini , C , Miyake , M , Hewitt , A W , Guo , X , Mazur , J , Huffman , J E , Williams , K M , Polasek , O , Campbell , H , Rudan , I , Vatavuk , Z , Wilson , J F , Joshi , P K , McMahon , G , St Pourcain , B , Evans , D M , Simpson , C L , Schwantes-An , T-H , Igo , R P , Mirshahi , A , Cougnard-Gregoire , A , Bellenguez , C , Blettner , M , Raitakari , O , Kähönen , M , Seppala , I , Zeller , T , Meitinger , T , Ried , J S , Gieger , C , Kaprio , J & Consortium Refractive Error Myopia 2016 , ' Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error ' , Nature Communications , vol. 7 , 11008 . https://doi.org/10.1038/ncomms11008

Title: Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
Author: Fan, Qiao; Verhoeven, Virginie J. M.; Wojciechowski, Robert; Barathi, Veluchamy A.; Hysi, Pirro G.; Guggenheim, Jeremy A.; Hoehn, Rene; Vitart, Veronique; Khawaja, Anthony P.; Yamashiro, Kenji; Hosseini, S. Mohsen; Lehtimaki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cecile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W.; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E.; Williams, Katie M.; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F.; Joshi, Peter K.; McMahon, George; St Pourcain, Beate; Evans, David M.; Simpson, Claire L.; Schwantes-An, Tae-Hwi; Igo, Robert P.; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Celine; Blettner, Maria; Raitakari, Olli; Kähönen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S.; Gieger, Christian; Kaprio, Jaakko; Consortium Refractive Error Myopia
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-04
Language: eng
Number of pages: 12
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/161393
Abstract: Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP x education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P <8.5 x 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Subject: RETINAL-PIGMENT EPITHELIUM
ACTIVATED PROTEIN-KINASE
RISK-FACTORS
OUTDOOR ACTIVITY
INCIDENT MYOPIA
TIME OUTDOORS
VARIANTS
EYE
POPULATION
RECEPTOR
3125 Otorhinolaryngology, ophthalmology
3142 Public health care science, environmental and occupational health
3111 Biomedicine
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