Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas

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dc.contributor University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka en
dc.contributor University of Helsinki, Department of Ophthalmology and Otorhinolaryngology en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor University of Helsinki, Clinicum en
dc.contributor.author Lundberg, Marie
dc.contributor.author Renkonen, Suvi
dc.contributor.author Haglund, Caj
dc.contributor.author Mattila, Petri S.
dc.contributor.author Leivo, Ilmo
dc.contributor.author Hagstrom, Jaana
dc.contributor.author Makitie, Antti A.
dc.date.accessioned 2016-05-09T07:17:02Z
dc.date.available 2016-05-09T07:17:02Z
dc.date.issued 2016-05-03
dc.identifier.citation Lundberg , M , Renkonen , S , Haglund , C , Mattila , P S , Leivo , I , Hagstrom , J & Makitie , A A 2016 , ' Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas ' , Acta Oto-Laryngologica , vol. 136 , no. 5 , pp. 501-505 . https://doi.org/10.3109/00016489.2015.1122227 en
dc.identifier.issn 0001-6489
dc.identifier.other PURE: 63305782
dc.identifier.other PURE UUID: f5f360e0-d874-476b-981a-642a767d89b3
dc.identifier.other WOS: 000373629100015
dc.identifier.other Scopus: 84954201573
dc.identifier.other ORCID: /0000-0001-6079-7881/work/49700400
dc.identifier.uri http://hdl.handle.net/10138/161459
dc.description.abstract Conclusions BMI-1 is an upstream repressor of tumor suppressor p16 and their inverse expression patterns have been linked with patient survival in OPSCC. In this material only p16 remained a relevant prognostic marker in OPSCC. Objectives HNSCC tumors carry variable phenotypes and clinical outcomes depending on their anatomical location. In OPSCC, expression of tumor suppressor p16 is used as a surrogate marker of HPV infection and has prognostic value. There are no good prognostic biomarkers for HNSCC tumors of other anatomical locations. Aim To study the expression patterns of p16 and BMI-1 in not only oropharyngeal but also oral, hypopharyngeal, and laryngeal squamous cell carcinomas and to clarify their putative connections with clinical parameters, survival, and each other. Method Hospital records on 130 patients (59 OPSCC, 18 OSCC, 20 HPSCC, and 33 LSCC) diagnosed between 1997-2008 at the Helsinki University Hospital, Finland, were reviewed. BMI-1 and p16 expressions were studied by immunohistochemistry. Results Sixty-eight per cent of OPSCC expressed p16 and expression correlated with lower age, lower T- and higher N-category, and with improved OS and DFS. BMI-1 expression was most prevalent in OPSCC and LSCC, but had no clinical correlations. No correlation between p16 and BMI-1 expression was found. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof Acta Oto-Laryngologica
dc.rights en
dc.subject predictive marker en
dc.subject HPV en
dc.subject oropharynx en
dc.subject stem cell en
dc.subject Oral en
dc.subject larynx en
dc.subject hypopharynx en
dc.subject SQUAMOUS-CELL CARCINOMA en
dc.subject HUMAN-PAPILLOMAVIRUS en
dc.subject EXPRESSION en
dc.subject CANCER en
dc.subject SURVIVAL en
dc.subject PREDICTS en
dc.subject MARKER en
dc.subject 3125 Otorhinolaryngology, ophthalmology en
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology en
dc.title Association of BMI-1 and p16 as prognostic factors for head and neck carcinomas en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.3109/00016489.2015.1122227
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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