Renal transplantation in infants

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http://hdl.handle.net/10138/161473

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Jalanko , H , Mattila , I & Holmberg , C 2016 , ' Renal transplantation in infants ' , Pediatric Nephrology , vol. 31 , no. 5 , pp. 725-735 . https://doi.org/10.1007/s00467-015-3144-0

Title: Renal transplantation in infants
Author: Jalanko, Hannu; Mattila, Ilkka; Holmberg, Christer
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-05
Language: eng
Number of pages: 11
Belongs to series: Pediatric Nephrology
ISSN: 0931-041X
URI: http://hdl.handle.net/10138/161473
Abstract: Renal transplantation (RTx) has become an accepted mode of therapy in infants with severe renal failure. The major indications are structural abnormalities of the urinary tract, congenital nephrotic syndrome, polycystic diseases, and neonatal kidney injury. Assessment of these infants needs expertise and time as well as active treatment before RTx to ensure optimal growth and development, and to avoid complications that could lead to permanent neurological defects. RTx can be performed already in infants weighing around 5 kg, but most operations occur in infants with a weight of 10 kg or more. Perioperative management focuses on adequate perfusion of the allograft and avoidance of thrombotic and other surgical complications. Important long-term issues include rejections, infections, graft function, growth, bone health, metabolic problems, neurocognitive development, adherence to medication, pubertal maturation, and quality of life. The overall outcome of infant RTx has dramatically improved, with long-term patient and graft survivals of over 90 and 80 %, respectively.
Subject: Infant
Kidney transplantation
Growth
Infections
Neurocognitive development
PEDIATRIC KIDNEY-TRANSPLANTATION
QUALITY-OF-LIFE
SOLID-ORGAN TRANSPLANTATION
ANTIBODY-MEDIATED REJECTION
ADULT-SIZED KIDNEYS
THAN 15 KG
EARLY-CHILDHOOD
SMALL CHILDREN
REPLACEMENT THERAPY
GRAFT FUNCTION
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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