Bacteria, phages and septicemia

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http://hdl.handle.net/10138/161747

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Gaidelyte , A , Vaara , M & Bamford , D H 2007 , ' Bacteria, phages and septicemia ' , PLoS One , vol. 2 , no. 11 , pp. e1145 . https://doi.org/10.1371/journal.pone.0001145

Title: Bacteria, phages and septicemia
Author: Gaidelyte, Ausra; Vaara, Martti; Bamford, Dennis H
Contributor: University of Helsinki, Institute of Biotechnology (-2009)
University of Helsinki, Haartman Institute (-2014)
University of Helsinki, Institute of Biotechnology (-2009)
Date: 2007
Language: eng
Number of pages: 5
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/161747
Abstract: The use of phages is an attractive option to battle antibiotic resistant bacteria in certain bacterial infections, but the role of phage ecology in bacterial infections is obscure. Here we surveyed the phage ecology in septicemia, the most severe type of bacterial infection. We observed that the majority of the bacterial isolates from septicemia patients spontaneously secreted phages active against other isolates of the same bacterial strain, but not to the strain causing the disease. Such phages were also detected in the initial blood cultures, indicating that phages are circulating in the blood at the onset of sepsis. The fact that most of the septicemic bacterial isolates carry functional prophages suggests an active role of phages in bacterial infections. Apparently, prophages present in sepsis-causing bacterial clones play a role in clonal selection during bacterial invasion.
Subject: 118 Biological sciences
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