Liprin-alpha 1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery

Show full item record



Permalink

http://hdl.handle.net/10138/161749

Citation

Pehkonen , H , von Nandelstadh , P , Karhemo , P-R , Lepikhova , T , Grenman , R , Lehti , K & Monni , O 2016 , ' Liprin-alpha 1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery ' , Scientific Reports , vol. 6 , 24486 . https://doi.org/10.1038/srep24486

Title: Liprin-alpha 1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery
Author: Pehkonen, Henna; von Nandelstadh, Pernilla; Karhemo, Piia-Riitta; Lepikhova, Tatiana; Grenman, Reidar; Lehti, Kaisa; Monni, Outi
Contributor: University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
University of Helsinki, Research Programs Unit
Date: 2016-04-14
Language: eng
Number of pages: 15
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/161749
Abstract: PPFIA1 is located at the 11q13 region, which is one of the most commonly amplified regions in several epithelial cancers including head and neck squamous cell carcinoma and breast carcinoma. Considering the location of PPFIA1 in this amplicon, we examined whether protein encoded by PPFIA1, liprin-alpha 1, possesses oncogenic properties in relevant carcinoma cell lines. Our results indicate that liprin-alpha 1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells. In non-invasive cells liprin-alpha 1 promotes expansive growth behavior with limited invasive capacity, whereas in invasive cells liprin-alpha 1 has significant impact on mesenchymal cancer cell invasion in three-dimensional collagen. Current results identify liprin-a1 as a novel regulator of the tumor cell intermediate filaments with differential oncogenic properties in actively proliferating or motile cells.
Subject: EPITHELIAL-MESENCHYMAL TRANSITION
EXTRACELLULAR-MATRIX DEGRADATION
EXPRESSION MICROARRAY ANALYSES
PROTEIN-TYROSINE-PHOSPHATASE
RESOLUTION COPY NUMBER
LIPRIN-ALPHA
BREAST-CANCER
GENE-EXPRESSION
POOR-PROGNOSIS
PODOSOMES
3111 Biomedicine
3122 Cancers
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
srep24486.pdf 2.699Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record