Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse : A Randomized Double-blind Controlled Multicentre Clinical Trial

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Akerstrom , U , Reitamo , S , Langeland , T , Berg , M , Rustad , L , Korhonen , L , Loden , M , Wiren , K , Grande , M , Skare , P & Svensson , A 2015 , ' Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse : A Randomized Double-blind Controlled Multicentre Clinical Trial ' , Acta Dermato-Venereologica , vol. 95 , no. 5 , pp. 587-592 . https://doi.org/10.2340/00015555-2051

Title: Comparison of Moisturizing Creams for the Prevention of Atopic Dermatitis Relapse : A Randomized Double-blind Controlled Multicentre Clinical Trial
Author: Akerstrom, Ulf; Reitamo, Sakari; Langeland, Tor; Berg, Mats; Rustad, Lisbeth; Korhonen, Laura; Loden, Marie; Wiren, Karin; Grande, Mats; Skare, Petra; Svensson, Ake
Contributor: University of Helsinki, Department of Dermatology, Allergology and Venereology
Date: 2015
Language: eng
Number of pages: 6
Belongs to series: Acta Dermato-Venereologica
ISSN: 0001-5555
URI: http://hdl.handle.net/10138/161809
Abstract: Atopic dermatitis (AD) affects adults and children and has a negative impact on quality of life. The present multicentre randomized double-blind controlled trial showed a barrier-improving cream (5% urea) to be superior to a reference cream in preventing eczema relapse in patients with AD (hazard ratio 0.634, p = 0.011). The risk of eczema relapse was reduced by 37% (95% confidence interval (95% CI) 10-55%). Median time to relapse in the test cream group and in the reference cream group was 22 days and 15 days, respectively (p = 0.013). At 6 months 26% of the patients in the test cream group were still eczema free, compared with 10% in the reference cream group. Thus, the barrier-improving cream significantly prolonged the eczema-free time compared with the reference cream and decreased the risk of eczema relapse. The test cream was well tolerated in patients with AD.
Subject: atopic dermatitis
atopic eczema
emollients
moisturizer
prevention
urea
SKIN BARRIER FUNCTION
ECZEMATOUS SKIN
DRY SKIN
CHILDREN
UREA
EMOLLIENTS
SUSCEPTIBILITY
3121 General medicine, internal medicine and other clinical medicine
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