Delineating Margins of Lentigo Maligna Using a Hyperspectral Imaging System

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Neittaanmäki-Perttu , N , Gronroos , M , Jeskanen , L , Polonen , I , Ranki , A , Saksela , O & Snellman , E 2015 , ' Delineating Margins of Lentigo Maligna Using a Hyperspectral Imaging System ' Acta Dermato-Venereologica , vol. 95 , no. 5 , pp. 549-552 . DOI: 10.2340/00015555-2010

Title: Delineating Margins of Lentigo Maligna Using a Hyperspectral Imaging System
Author: Neittaanmäki-Perttu, Noora; Gronroos, Mari; Jeskanen, Leila; Polonen, Ilkka; Ranki, Annamari; Saksela, Olli; Snellman, Erna
Contributor: University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
University of Helsinki, Department of Dermatology, Allergology and Venereology
Date: 2015
Language: eng
Number of pages: 4
Belongs to series: Acta Dermato-Venereologica
ISSN: 0001-5555
URI: http://hdl.handle.net/10138/161811
Abstract: Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimated clinically, and confirmed histologically. A total of 14 LMs and 5 LIVIMs in 19 patients were included. HIS analysis matched the histopathological analysis in 18/19 (94.7%) cases while in 1/19 (5.3%) cases HIS showed lesion extension not confirmed by histopathology (false positives). Compared to clinical examination, HIS defined lesion borders more accurately in 10/19 (52.6%) of cases (wider, n=7 or smaller, n=3) while in 8/19 (42.1%) cases lesion borders were the same as delineated clinically as confirmed histologically. Thus, HIS is useful for the detection of subclinical LM/LMM borders.
Subject: lentigo maligna
lentigo maligna melanoma
tumour margin assessment
hyperspectral imaging
CONFOCAL MICROSCOPY
SKIN-CANCER
MELANOMA
MANAGEMENT
ALGORITHM
SURGERY
CARE
3121 Internal medicine
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