Kiiski , V , Karlsson , O , Remitz , A & Reitamo , S 2015 , ' High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis ' , Acta Dermato-Venereologica , vol. 95 , no. 8 , pp. 943-947 . https://doi.org/10.2340/00015555-2126
Title: | High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis |
Author: | Kiiski, Ville; Karlsson, Oskar; Remitz, Anita; Reitamo, Sakari |
Contributor organization: | Clinicum Department of Dermatology, Allergology and Venereology |
Date: | 2015 |
Language: | eng |
Number of pages: | 5 |
Belongs to series: | Acta Dermato-Venereologica |
ISSN: | 0001-5555 |
DOI: | https://doi.org/10.2340/00015555-2126 |
URI: | http://hdl.handle.net/10138/161813 |
Abstract: | Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14-78 years) with a mean follow-up of 4.15 years. High baseline IgE (>= 10,000 IU/ml) was the most important patient-related factor for a poor longterm outcome, being negatively associated with good treatment response (odds ratio (OR) 0.062, p=0.002). Only 14.3% of patients with this high baseline IgE achieved a good treatment response in follow-up, compared with 79.7% in patients with lower ( |
Subject: |
atopic dermatitis
immunoglobulin E biomarker treatment response EOSINOPHIL CATIONIC PROTEIN IMMUNOGLOBULIN-E DISEASE CHILDREN FILAGGRIN SEVERITY BARRIER ECZEMA SENSITIZATION INDIVIDUALS 3121 General medicine, internal medicine and other clinical medicine |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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