High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis

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Kiiski , V , Karlsson , O , Remitz , A & Reitamo , S 2015 , ' High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis ' , Acta Dermato-Venereologica , vol. 95 , no. 8 , pp. 943-947 . https://doi.org/10.2340/00015555-2126

Title: High Serum Total IgE Predicts Poor Long-term Outcome in Atopic Dermatitis
Author: Kiiski, Ville; Karlsson, Oskar; Remitz, Anita; Reitamo, Sakari
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum

Date: 2015
Language: eng
Number of pages: 5
Belongs to series: Acta Dermato-Venereologica
ISSN: 0001-5555
DOI: https://doi.org/10.2340/00015555-2126
URI: http://hdl.handle.net/10138/161813
Abstract: Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14-78 years) with a mean follow-up of 4.15 years. High baseline IgE (>= 10,000 IU/ml) was the most important patient-related factor for a poor longterm outcome, being negatively associated with good treatment response (odds ratio (OR) 0.062, p=0.002). Only 14.3% of patients with this high baseline IgE achieved a good treatment response in follow-up, compared with 79.7% in patients with lower (
Subject: atopic dermatitis
immunoglobulin E
biomarker
treatment response
EOSINOPHIL CATIONIC PROTEIN
IMMUNOGLOBULIN-E
DISEASE
CHILDREN
FILAGGRIN
SEVERITY
BARRIER
ECZEMA
SENSITIZATION
INDIVIDUALS
3121 General medicine, internal medicine and other clinical medicine
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