Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium

Show full item record



Permalink

http://hdl.handle.net/10138/161891

Citation

Morris , R W , Taylor , A E , Fluharty , M E , Bjorngaard , J H , Asvold , B O , Gabrielsen , M E , Campbell , A , Marioni , R , Kumari , M , Korhonen , T , Mannisto , S , Marques-Vidal , P , Kaakinen , M , Cavadino , A , Postmus , I , Husemoen , L L N , Skaaby , T , Ahluwalia , T V S , Treur , J L , Willemsen , G , Dale , C , Wannamethee , S G , Lahti , J , Palotie , A , Räikkönen , K , McConnachie , A , Padmanabhan , S , Wong , A , Dalgard , C , Paternoster , L , Ben-Shlomo , Y , Tyrrell , J , Horwood , J , Fergusson , D M , Kennedy , M A , Nohr , E A , Christiansen , L , Kyvik , K O , Kuh , D , Watt , G , Eriksson , J G , Whincup , P H , Vink , J M , Boomsma , D I , Smith , G D , Lawlor , D , Linneberg , A , Ford , I , Jukema , J W , Power , C , Hypponen , E , Jarvelin , M-R , Preisig , M , Borodulin , K , Kaprio , J , Kivimaki , M , Smith , B H , Hayward , C , Romundstad , P R , Sorensen , T I A , Munafo , M R & Sattar , N 2015 , ' Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium ' , BMJ Open , vol. 5 , no. 8 , 008808 . https://doi.org/10.1136/bmjopen-2015-008808

Title: Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium
Author: Morris, Richard W.; Taylor, Amy E.; Fluharty, Meg E.; Bjorngaard, Johan H.; Asvold, Bjorn Olav; Gabrielsen, Maiken Elvestad; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Mannisto, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N.; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L.; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S. Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgard, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M.; Kennedy, Martin A.; Nohr, Ellen A.; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G.; Whincup, Peter H.; Vink, Jacqueline M.; Boomsma, Dorret I.; Smith, George Davey; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J. Wouter; Power, Chris; Hypponen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H.; Hayward, Caroline; Romundstad, Pal R.; Sorensen, Thorkild I. A.; Munafo, Marcus R.; Sattar, Naveed
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Behavioural Sciences
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Behavioural Sciences
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2015
Language: eng
Number of pages: 10
Belongs to series: BMJ Open
ISSN: 2044-6055
URI: http://hdl.handle.net/10138/161891
Abstract: Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants: 148 731 current, former and neversmokers of European ancestry aged >= 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% Cl -0.57% to - 0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% Cl - 0.42% to -0.19), -0.08% (-0.19% to 0.03%) and - 0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.
Subject: CORONARY-HEART-DISEASE
BODY-MASS INDEX
CIGARETTE-SMOKING
WEIGHT CONCERNS
RISK-FACTORS
MORTALITY
ASSOCIATION
ADIPOSITY
WOMEN
MEN
3142 Public health care science, environmental and occupational health
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
e008808.full.pdf 1.101Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record