Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium

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Morris , R W , Taylor , A E , Fluharty , M E , Bjorngaard , J H , Asvold , B O , Gabrielsen , M E , Campbell , A , Marioni , R , Kumari , M , Korhonen , T , Mannisto , S , Marques-Vidal , P , Kaakinen , M , Cavadino , A , Postmus , I , Husemoen , L L N , Skaaby , T , Ahluwalia , T V S , Treur , J L , Willemsen , G , Dale , C , Wannamethee , S G , Lahti , J , Palotie , A , Räikkönen , K , McConnachie , A , Padmanabhan , S , Wong , A , Dalgard , C , Paternoster , L , Ben-Shlomo , Y , Tyrrell , J , Horwood , J , Fergusson , D M , Kennedy , M A , Nohr , E A , Christiansen , L , Kyvik , K O , Kuh , D , Watt , G , Eriksson , J G , Whincup , P H , Vink , J M , Boomsma , D I , Smith , G D , Lawlor , D , Linneberg , A , Ford , I , Jukema , J W , Power , C , Hypponen , E , Jarvelin , M-R , Preisig , M , Borodulin , K , Kaprio , J , Kivimaki , M , Smith , B H , Hayward , C , Romundstad , P R , Sorensen , T I A , Munafo , M R & Sattar , N 2015 , ' Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium ' , BMJ Open , vol. 5 , no. 8 , 008808 . https://doi.org/10.1136/bmjopen-2015-008808

Titel: Heavier smoking may lead to a relative increase in waist circumference : evidence for causal relationship from a Mendelian iandomisation meta-analysis. The CARTA consortium
Författare: Morris, Richard W.; Taylor, Amy E.; Fluharty, Meg E.; Bjorngaard, Johan H.; Asvold, Bjorn Olav; Gabrielsen, Maiken Elvestad; Campbell, Archie; Marioni, Riccardo; Kumari, Meena; Korhonen, Tellervo; Mannisto, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N.; Skaaby, Tea; Ahluwalia, Tarun Veer Singh; Treur, Jorien L.; Willemsen, Gonneke; Dale, Caroline; Wannamethee, S. Goya; Lahti, Jari; Palotie, Aarno; Räikkönen, Katri; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgard, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, David M.; Kennedy, Martin A.; Nohr, Ellen A.; Christiansen, Lene; Kyvik, Kirsten Ohm; Kuh, Diana; Watt, Graham; Eriksson, Johan G.; Whincup, Peter H.; Vink, Jacqueline M.; Boomsma, Dorret I.; Smith, George Davey; Lawlor, Debbie; Linneberg, Allan; Ford, Ian; Jukema, J. Wouter; Power, Chris; Hypponen, Elina; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, Blair H.; Hayward, Caroline; Romundstad, Pal R.; Sorensen, Thorkild I. A.; Munafo, Marcus R.; Sattar, Naveed
Upphovmannens organisation: Clinicum
Tellervo Korhonen / Principal Investigator
Department of Public Health
Behavioural Sciences
Institute for Molecular Medicine Finland
Aarno Palotie / Principal Investigator
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Jaakko Kaprio / Principal Investigator
Developmental Psychology Research Group
Genomics of Neurological and Neuropsychiatric Disorders
Genetic Epidemiology
Datum: 2015
Språk: eng
Sidantal: 10
Tillhör serie: BMJ Open
ISSN: 2044-6055
DOI: https://doi.org/10.1136/bmjopen-2015-008808
Permanenta länken (URI): http://hdl.handle.net/10138/161891
Abstrakt: Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants: 148 731 current, former and neversmokers of European ancestry aged >= 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% Cl -0.57% to - 0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% Cl - 0.42% to -0.19), -0.08% (-0.19% to 0.03%) and - 0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.
Subject: CORONARY-HEART-DISEASE
BODY-MASS INDEX
CIGARETTE-SMOKING
WEIGHT CONCERNS
RISK-FACTORS
MORTALITY
ASSOCIATION
ADIPOSITY
WOMEN
MEN
3142 Public health care science, environmental and occupational health
Referentgranskad: Ja
Licens: cc_by_nc
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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