Circulating tumor DNA in early-stage breast cancer : personalized biomarkers for occult metastatic disease and risk of relapse?

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http://hdl.handle.net/10138/161935

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af Hallstrom , T M , Puhka , M & Kallioniemi , O 2015 , ' Circulating tumor DNA in early-stage breast cancer : personalized biomarkers for occult metastatic disease and risk of relapse? ' , EMBO molecular medicine , vol. 7 , no. 8 , pp. 994-995 . https://doi.org/10.15252/emmm.201505332

Titel: Circulating tumor DNA in early-stage breast cancer : personalized biomarkers for occult metastatic disease and risk of relapse?
Författare: af Hallstrom, Taija M.; Puhka, Maija; Kallioniemi, Olli
Upphovmannens organisation: Institute for Molecular Medicine Finland
Olli-Pekka Kallioniemi / Principal Investigator
Datum: 2015-08
Språk: eng
Sidantal: 2
Tillhör serie: EMBO molecular medicine
ISSN: 1757-4676
DOI: https://doi.org/10.15252/emmm.201505332
Permanenta länken (URI): http://hdl.handle.net/10138/161935
Abstrakt: The availability of blood-based markers topredict response of a solid tumor to treatment, estimate patient prognosis and diagnose relapse well before clinical symptoms arise, is a long-standing hope in clinical oncology. Ideally, assays designed to provide such information should be inexpensive (at least in the foreseeable future), simple, and, of course, predictive of the clinical evolution of the disease. While early research focused on circulating glycosylated tumor-derived protein biomarkers, the focus is now rapidly shifting to new opportunities, such as circulating tumor cells, extracellular vesicles, micro-RNAs and cancer-derived cell-free DNA a.k.a. circulating tumor-derived DNA (ctDNA).
Subject: 3111 Biomedicine
Referentgranskad: Nej
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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