Microtechnologies to fuel neurobiological research with nanometer precision

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http://hdl.handle.net/10138/161996

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Brunello , C , Jokinen , V , Sakha , P , Terazono , H , Nomura , F , Kaneko , T , Lauri , S , Franssila , S , Rivera Baeza , C , Yasuda , K & Huttunen , H J 2013 , ' Microtechnologies to fuel neurobiological research with nanometer precision ' , Journal of Nanobiotechnology , vol. 11 , no. April , 11 . https://doi.org/10.1186/1477-3155-11-11

Title: Microtechnologies to fuel neurobiological research with nanometer precision
Author: Brunello, Cecilia; Jokinen, Ville; Sakha, Prasanna; Terazono, Hideyuki; Nomura, Fumimasa; Kaneko, Tomoyuki; Lauri, Sari; Franssila, Sami; Rivera Baeza, Claudio; Yasuda, Kenji; Huttunen, Henri Juhani
Contributor: University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
University of Helsinki, Biosciences
University of Helsinki, Neuroscience Center
University of Helsinki, Neuroscience Center
Date: 2013-04-10
Language: eng
Number of pages: 8
Belongs to series: Journal of Nanobiotechnology
ISSN: 1477-3155
URI: http://hdl.handle.net/10138/161996
Abstract: The interface between engineering and molecular life sciences has been fertile ground for advancing our understanding of complex biological systems. Engineered microstructures offer a diverse toolbox for cellular and molecular biologists to direct the placement of cells and small organisms, and to recreate biological functions in vitro: cells can be positioned and connected in a designed fashion, and connectivity and community effects of cells studied. Because of the highly polar morphology and finely compartmentalized functions of neurons, microfabricated cell culture systems and related on-chip technologies have become an important enabling platform for studying development, function and degeneration of the nervous system at the molecular and cellular level. Here we review some of the compartmentalization techniques developed so far to highlight how high- precision control of neuronal connectivity allows new approaches for studying axonal and synaptic biology.
Subject: 3112 Neurosciences
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