Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life

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Eriksson , J G , Venojarvi , M & Osmond , C 2016 , ' Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life ' International Journal of Endocrinology . DOI: 10.1155/2016/3838646

Title: Prenatal and Childhood Growth, Chemerin Concentrations, and Metabolic Health in Adult Life
Author: Eriksson, Johan G.; Venojarvi, Mika; Osmond, Clive
Contributor: University of Helsinki, Johan Eriksson / Principal Investigator
Date: 2016
Language: eng
Number of pages: 6
Belongs to series: International Journal of Endocrinology
ISSN: 1687-8337
URI: http://hdl.handle.net/10138/162113
Abstract: Several noncommunicable diseases have their origins in early developmental phases. One factor possibly explaining the association between early growth and later health could be adipocyte function. The objective of this study was to assess the association between the adipocytokine chemerin and early growth and later health. 1074 participants from Helsinki Birth Cohort Study born 19341944 with information on prenatal and childhood growth participated. Metabolic outcomes include glucose tolerance, adiposity, and chemerin concentration. Mean chemerin concentrations were 5.0 ng/mL higher in women than in men (95% CI 2.7 to 7.2, P <0.001). The strongest correlate of chemerin concentration was adult waist circumference and body fat percentage (r = 0.22, P <0.001 and r= 0.21, P <0.001, resp.). After adjustment for body fat percentage, chemerin concentration was 5.4 ng/mL lower in subjects with type 2 diabetes than in those with normal glucose tolerance (-0.2 to 10.9, P = 0.06). It was 3.0 ng/mL higher in those with metabolic syndrome than in those without (0.6 to 5.3, P = 0.01). No measure of early growth was associated with chemerin concentration. Our findings do not support a role for chemerin in linking early growth with later metabolic health.
Subject: ADIPOKINE CHEMERIN
DIABETES-MELLITUS
NONDIABETIC OBESE
ADIPOSE-TISSUE
BIRTH COHORT
SERUM-LEVELS
PLASMA
INFLAMMATION
INSULIN
PREECLAMPSIA
3121 Internal medicine
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