Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins

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Robciuc , M R , Naukkarinen , J , Ortega-Alonso , A , Tyynismaa , H , Raivio , T , Rissanen , A , Kaprio , J , Ehnholm , C , Jauhiainen , M & Pietiläinen , K H 2011 , ' Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins ' , Journal of Lipid Research , vol. 52 , no. 8 , pp. 1575-1582 . https://doi.org/10.1194/jlr.P015867

Title: Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins
Author: Robciuc, Marius R.; Naukkarinen, Jussi; Ortega-Alonso, Alfredo; Tyynismaa, Henna; Raivio, Taneli; Rissanen, Aila; Kaprio, Jaakko; Ehnholm, Christian; Jauhiainen, Matti; Pietiläinen, Kirsi Hannele
Contributor organization: Institute for Molecular Medicine Finland
Department of Medicine
Department of Psychiatry
Hjelt Institute (-2014)
Department of Public Health
Research Programme for Molecular Neurology
Medicum
Department of Physiology
Children's Hospital
Clinicum
Raivio Group
HUS Children and Adolescents
HUS Psychiatry
HUS Internal Medicine and Rehabilitation
Genetic Epidemiology
Date: 2011
Language: eng
Number of pages: 8
Belongs to series: Journal of Lipid Research
ISSN: 0022-2275
DOI: https://doi.org/10.1194/jlr.P015867
URI: http://hdl.handle.net/10138/162187
Abstract: Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated with obesity-related parameters in humans. Altogether, 75 dizygotic (DZ) and 46 monozygotic (MZ) twin pairs were studied, from the FinnTwin12 and FinnTwin16 cohorts. Among the MZ pairs, 21 were discordant for body mass index (BMI) (intra-pair BMI-difference >2.5 kg/m², age 23-33 years). Serum Angptl4 (s-Angptl4) levels were measured by ELISA, and adipose tissue gene expression was analyzed by genome-wide transcript profiling. In MZ twin pairs discordant for BMI, s-Angptl4 and adipose tissue ANGPTL4 mRNA (at-ANGPTL4) levels were significantly decreased (P = 0.04 and P = 0.03, respectively) in obese twins as compared with their nonobese cotwins. In all twins, intra-pair differences in s-Angptl4 levels were inversely correlated with intra-pair differences in BMI (r = -0.27, P = 0.003). In individual MZ twins, at-ANGPTL4 expression was inversely correlated with BMI (r = -0.44, P = 0.001) and positively correlated with at-LIPE (r = 0.24, P = 0.01) and at-ABHD5 (r = 0.41, P = 0.005) expression. Our results demonstrated that variation in Angptl4 concentration was only modestly accounted for by genetic factors and suggest a role for Angptl4 in acquired obesity in humans.
Subject: Angptl4
heritability
twin pairs
obesity-discordant monozygotic twins
FREE FATTY-ACIDS
TARGET GENE
PLASMA
ANGIOGENESIS
METASTASIS
INHIBITION
METABOLISM
RESISTANCE
LIPOLYSIS
TUMORS
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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