Toppinen , M , Perdomo , M , Palo , J U , Simmonds , P , Lycett , S J , Soderlund-Venermo , M , Sajantila , A & Hedman , K 2015 , ' Bones hold the key to DNA virus history and epidemiology ' , Scientific Reports , vol. 5 , 17226 . https://doi.org/10.1038/srep17226
Title: | Bones hold the key to DNA virus history and epidemiology |
Author: | Toppinen, M.; Perdomo, Maria; Palo, J. U.; Simmonds, P.; Lycett, S. J.; Soderlund-Venermo, M.; Sajantila, A.; Hedman, K. |
Contributor organization: | Department of Virology Medicum Forensic Medicine Klaus Hedman / Principal Investigator Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact Virus infections and immunity |
Date: | 2015-11-27 |
Language: | eng |
Number of pages: | 8 |
Belongs to series: | Scientific Reports |
ISSN: | 2045-2322 |
DOI: | https://doi.org/10.1038/srep17226 |
URI: | http://hdl.handle.net/10138/162422 |
Abstract: | DNA in human skeletal remains represents an important historical source of host genomic information and potentially of infecting viruses. However, little is known about viral persistence in bone. We searched ca. 70-year-old long bones of putative Finnish casualties from World War II for parvovirus B19 (B19V) DNA, and found a remarkable prevalence of 45%. The viral sequences were exclusively of genotypes 2 (n = 41), which disappeared from circulation in 1970's, or genotype 3 (n = 2), which has never been reported in Northern Europe. Based on mitochondrial and Y-chromosome profiling, the two individuals carrying B19V genotype 3 were likely from the Soviet Red Army. The most recent common ancestor for all genotypes was estimated at early 1800s. This work demonstrates the forms of B19V that circulated in the first half of the 20th century and provides the first evidence of the suitability of bone for exploration of DNA viruses. |
Subject: |
HUMAN PARVOVIRUS B19
MARROW CELL-CULTURES HUMAN ERYTHROVIRUSES VIRAL EVOLUTION PERSISTENCE INFECTION IDENTIFICATION TISSUE REPLICATION EMERGENCE 3111 Biomedicine |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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