Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes

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Sober , S , Reiman , M , Kikas , T , Rull , K , Inno , R , Vaas , P , Teesalu , P , Marti , J M L , Mattila , P & Laan , M 2015 , ' Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes ' Scientific Reports , vol. 5 , 13336 . DOI: 10.1038/srep13336

Title: Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes
Author: Sober, Siim; Reiman, Mario; Kikas, Triin; Rull, Kristiina; Inno, Rain; Vaas, Pille; Teesalu, Pille; Marti, Jesus M. Lopez; Mattila, Pirkko; Laan, Maris
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
Date: 2015-08-13
Language: eng
Number of pages: 17
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/162435
Abstract: One in five pregnant women suffer from gestational complications, prevalently driven by placental malfunction. Using RNASeq, we analyzed differential placental gene expression in cases of normal gestation, late-onset preeclampsia (LO-PE), gestational diabetes (GD) and pregnancies ending with the birth of small-for-gestational-age (SGA) or large-for-gestational-age (LGA) newborns (n = 8/group). In all groups, the highest expression was detected for small noncoding RNAs and genes specifically implicated in placental function and hormonal regulation. The transcriptome of LO-PE placentas was clearly distinct, showing statistically significant (after FDR) expressional disturbances for hundreds of genes. Taqman RT-qPCR validation of 45 genes in an extended sample (n = 24/group) provided concordant results. A limited number of transcription factors including LRF, SP1 and AP2 were identified as possible drivers of these changes. Notable differences were detected in differential expression signatures of LO-PE subtypes defined by the presence or absence of intrauterine growth restriction (IUGR). LO-PE with IUGR showed higher correlation with SGA and LO-PE without IUGR with LGA placentas. Whereas changes in placental transcriptome in SGA, LGA and GD cases were less prominent, the overall profiles of expressional disturbances overlapped among pregnancy complications providing support to shared placental responses. The dataset represent a rich catalogue for potential biomarkers and therapeutic targets.
Subject: PROGESTERONE-RECEPTOR ISOFORM
BIOCHEMICAL MARKERS
GROWTH RESTRICTION
GENE-EXPRESSION
MESSENGER-RNA
FETAL-GROWTH
SYNCYTIOTROPHOBLASTS
DIFFERENTIATION
DISEASE
PROTEIN
1184 Genetics, developmental biology, physiology
3111 Biomedicine
3123 Gynaecology and paediatrics
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