The effect of music performance on the transcriptome of professional musicians

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http://hdl.handle.net/10138/162449

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Kanduri , C , Kuusi , T , Ahvenainen , M , Philips , A K , Lahdesmaki , H & Jarvela , I 2015 , ' The effect of music performance on the transcriptome of professional musicians ' , Scientific Reports , vol. 5 , 9506 . https://doi.org/10.1038/srep09506

Titel: The effect of music performance on the transcriptome of professional musicians
Författare: Kanduri, Chakravarthi; Kuusi, Tuire; Ahvenainen, Minna; Philips, Anju K.; Lahdesmaki, Harri; Jarvela, Irma
Upphovmannens organisation: Department of Medical and Clinical Genetics
Medicum
Datum: 2015-03-25
Språk: eng
Sidantal: 7
Tillhör serie: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep09506
Permanenta länken (URI): http://hdl.handle.net/10138/162449
Abstrakt: Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a 'music-free' control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.
Subject: DIFFERENTIALLY EXPRESSED GENES
SYNAPTIC PLASTICITY
REGULATED GENES
ZEBRA FINCH
BRAIN
MICROARRAY
BLOOD
FOS
MODULATION
EMOTION
1184 Genetics, developmental biology, physiology
3111 Biomedicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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