The effect of music performance on the transcriptome of professional musicians

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dc.contributor.author Kanduri, Chakravarthi
dc.contributor.author Kuusi, Tuire
dc.contributor.author Ahvenainen, Minna
dc.contributor.author Philips, Anju K.
dc.contributor.author Lahdesmaki, Harri
dc.contributor.author Jarvela, Irma
dc.date.accessioned 2016-05-19T13:32:01Z
dc.date.available 2016-05-19T13:32:01Z
dc.date.issued 2015-03-25
dc.identifier.citation Kanduri , C , Kuusi , T , Ahvenainen , M , Philips , A K , Lahdesmaki , H & Jarvela , I 2015 , ' The effect of music performance on the transcriptome of professional musicians ' , Scientific Reports , vol. 5 , 9506 . https://doi.org/10.1038/srep09506
dc.identifier.other PURE: 48407347
dc.identifier.other PURE UUID: d0d6f0a8-fa8d-4d74-8242-700fcd611fe9
dc.identifier.other WOS: 000351705500001
dc.identifier.other Scopus: 84926301757
dc.identifier.other ORCID: /0000-0002-1770-6187/work/42752762
dc.identifier.uri http://hdl.handle.net/10138/162449
dc.description.abstract Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a 'music-free' control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject DIFFERENTIALLY EXPRESSED GENES
dc.subject SYNAPTIC PLASTICITY
dc.subject REGULATED GENES
dc.subject ZEBRA FINCH
dc.subject BRAIN
dc.subject MICROARRAY
dc.subject BLOOD
dc.subject FOS
dc.subject MODULATION
dc.subject EMOTION
dc.subject 1184 Genetics, developmental biology, physiology
dc.subject 3111 Biomedicine
dc.title The effect of music performance on the transcriptome of professional musicians en
dc.type Article
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization Medicum
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/srep09506
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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