Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

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Mahajan , A , Sim , X , Ng , H J , Manning , A , Rivas , M A , Highland , H M , Locke , A E , Grarup , N , Im , H K , Cingolani , P , Flannick , J , Fontanillas , P , Fuchsberger , C , Gaulton , K J , Teslovich , T M , Rayner , N W , Robertson , N R , Beer , N L , Rundle , J K , Bork-Jensen , J , Ladenvall , C , Blancher , C , Buck , D , Buck , G , Burtt , N P , Gabriel , S , Gjesing , A P , Groves , C J , Hollensted , M , Huyghe , J R , Jackson , A U , Jun , G , Justesen , J M , Mangino , M , Murphy , J , Neville , M , Onofrio , R , Small , K S , Stringham , H M , Syvanen , A-C , Trakalo , J , Abecasis , G , Bell , G I , Blangero , J , Cox , N J , Duggirala , R , Isomaa , B , Tuomi , T , Tuomilehto , J , Groop , L , T2D-GENES Consortium & Go T2D Consortium 2015 , ' Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus ' PLoS Genetics , vol. 11 , no. 1 , 1004876 . DOI: 10.1371/journal.pgen.1004876

Title: Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Author: Mahajan, Anubha; Sim, Xueling; Ng, Hui Jin; Manning, Alisa; Rivas, Manuel A.; Highland, Heather M.; Locke, Adam E.; Grarup, Niels; Im, Hae Kyung; Cingolani, Pablo; Flannick, Jason; Fontanillas, Pierre; Fuchsberger, Christian; Gaulton, Kyle J.; Teslovich, Tanya M.; Rayner, N. William; Robertson, Neil R.; Beer, Nicola L.; Rundle, Jana K.; Bork-Jensen, Jette; Ladenvall, Claes; Blancher, Christine; Buck, David; Buck, Gemma; Burtt, Noel P.; Gabriel, Stacey; Gjesing, Anette P.; Groves, Christopher J.; Hollensted, Mette; Huyghe, Jeroen R.; Jackson, Anne U.; Jun, Goo; Justesen, Johanne Marie; Mangino, Massimo; Murphy, Jacquelyn; Neville, Matt; Onofrio, Robert; Small, Kerrin S.; Stringham, Heather M.; Syvanen, Ann-Christine; Trakalo, Joseph; Abecasis, Goncalo; Bell, Graeme I.; Blangero, John; Cox, Nancy J.; Duggirala, Ravindranath; Isomaa, Bo; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Groop, Leif; T2D-GENES Consortium; Go T2D Consortium
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Medicine
University of Helsinki, Department of Public Health (-2009)
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2015-01
Language: eng
Number of pages: 25
Belongs to series: PLoS Genetics
ISSN: 1553-7390
URI: http://hdl.handle.net/10138/162491
Subject: TYPE-2 DIABETES RISK
FASTING PLASMA-GLUCOSE
GENETIC ARCHITECTURE
TRIGLYCERIDE LEVELS
QUANTITATIVE TRAIT
P446L VARIANT
ASSOCIATION
GENOME
PROTEIN
POLYMORPHISMS
3111 Biomedicine
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