Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma : neuroprotection, neuroregeneration and neuroplasticity

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Smedowski , A , Liu , X , Pietrucha-Dutczak , M , Matuszek , I , Varjosalo , M & Lewin-Kowalik , J 2016 , ' Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma : neuroprotection, neuroregeneration and neuroplasticity ' Scientific Reports , vol. 6 , 23187 . DOI: 10.1038/srep23187

Title: Predegenerated Schwann cells-a novel prospect for cell therapy for glaucoma : neuroprotection, neuroregeneration and neuroplasticity
Author: Smedowski, Adrian; Liu, Xiaonan; Pietrucha-Dutczak, Marita; Matuszek, Iwona; Varjosalo, Markku; Lewin-Kowalik, Joanna
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
Date: 2016-04-01
Language: eng
Number of pages: 15
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/162511
Abstract: Glaucoma is an optic neuropathy that leads to irreversible blindness. Because the current therapies are not sufficient to protect against glaucoma-induced visual impairment, new treatment approaches are necessary to prevent disease progression. Cell transplantation techniques are currently considered to be among the most promising opportunities for nervous system damage treatment. The beneficial effects of undifferentiated cells have been investigated in experimental models of glaucoma, however experiments were accompanied by various barriers, which would make putative treatment difficult or even impossible to apply in a clinical setting. The novel therapy proposed in our study creates conditions to eliminate some of the identified barriers described for precursor cells transplantation and allows us to observe direct neuroprotective and pro-regenerative effects in ongoing optic neuropathy without additional modifications to the transplanted cells. We demonstrated that the proposed novel Schwann cell therapy might be promising, effective and easy to apply, and is safer than the alternative cell therapies for the treatment of glaucoma.
Subject: RETINAL GANGLION-CELLS
OPEN-ANGLE GLAUCOMA
RAT SPINAL-CORD
STEM-CELLS
IN-VITRO
INTRAOCULAR-PRESSURE
NEUROTROPHIC FACTORS
NERVE GRAFTS
NEURITE OUTGROWTH
AXON REGENERATION
3125 Otorhinolaryngology, ophthalmology
1182 Biochemistry, cell and molecular biology
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