Selective effect of cell membrane on synaptic neurotransmission

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Postila , P A , Vattulainen , I & Rog , T J 2016 , ' Selective effect of cell membrane on synaptic neurotransmission ' Scientific Reports , vol. 6 , 19345 . DOI: 10.1038/srep19345

Title: Selective effect of cell membrane on synaptic neurotransmission
Author: Postila, Pekka A.; Vattulainen, Ilpo; Rog, Tomasz Jakub
Contributor: University of Helsinki, Department of Physics
University of Helsinki, Department of Physics
Date: 2016-01-19
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/162523
Abstract: Atomistic molecular dynamics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different membrane environments. The results provide compelling evidence that NTs are divided into membrane-binding and membrane-nonbinding molecules. NTs adhere to the postsynaptic membrane surface whenever the ligand-binding sites of their synaptic receptors are buried in the lipid bilayer. In contrast, NTs that have extracellular ligand-binding sites do not have a similar tendency to adhere to the membrane surface. This finding is a seemingly simple yet important addition to the paradigm of neurotransmission, essentially dividing it into membrane-independent and membrane-dependent mechanisms. Moreover, the simulations also indicate that the lipid composition especially in terms of charged lipids can affect the membrane partitioning of NTs. The revised paradigm, highlighting the importance of cell membrane and specific lipids for neurotransmission, should to be of interest to neuroscientists, drug industry and the general public alike.
Subject: LIPID-BILAYER MEMBRANES
MOLECULAR-DYNAMICS
AGONIST DYSIHERBAINE
PLASMA-MEMBRANES
FORCE-FIELD
RECEPTOR
CHOLESTEROL
AFFINITY
PERMEABILITY
TRANSPORTERS
1182 Biochemistry, cell and molecular biology
114 Physical sciences
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