Selective effect of cell membrane on synaptic neurotransmission

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dc.contributor.author Postila, Pekka A.
dc.contributor.author Vattulainen, Ilpo
dc.contributor.author Rog, Tomasz Jakub
dc.date.accessioned 2016-05-20T08:17:04Z
dc.date.available 2016-05-20T08:17:04Z
dc.date.issued 2016-01-19
dc.identifier.citation Postila , P A , Vattulainen , I & Rog , T J 2016 , ' Selective effect of cell membrane on synaptic neurotransmission ' , Scientific Reports , vol. 6 , 19345 . https://doi.org/10.1038/srep19345
dc.identifier.other PURE: 59525397
dc.identifier.other PURE UUID: 5edbc20a-ad31-4ee8-9f45-96548be734dd
dc.identifier.other WOS: 000368330000001
dc.identifier.other Scopus: 84955442236
dc.identifier.other ORCID: /0000-0001-7408-3214/work/29063564
dc.identifier.uri http://hdl.handle.net/10138/162523
dc.description.abstract Atomistic molecular dynamics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different membrane environments. The results provide compelling evidence that NTs are divided into membrane-binding and membrane-nonbinding molecules. NTs adhere to the postsynaptic membrane surface whenever the ligand-binding sites of their synaptic receptors are buried in the lipid bilayer. In contrast, NTs that have extracellular ligand-binding sites do not have a similar tendency to adhere to the membrane surface. This finding is a seemingly simple yet important addition to the paradigm of neurotransmission, essentially dividing it into membrane-independent and membrane-dependent mechanisms. Moreover, the simulations also indicate that the lipid composition especially in terms of charged lipids can affect the membrane partitioning of NTs. The revised paradigm, highlighting the importance of cell membrane and specific lipids for neurotransmission, should to be of interest to neuroscientists, drug industry and the general public alike. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject LIPID-BILAYER MEMBRANES
dc.subject MOLECULAR-DYNAMICS
dc.subject AGONIST DYSIHERBAINE
dc.subject PLASMA-MEMBRANES
dc.subject FORCE-FIELD
dc.subject RECEPTOR
dc.subject CHOLESTEROL
dc.subject AFFINITY
dc.subject PERMEABILITY
dc.subject TRANSPORTERS
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 114 Physical sciences
dc.title Selective effect of cell membrane on synaptic neurotransmission en
dc.type Article
dc.contributor.organization Department of Physics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/srep19345
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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