Genome derived insights into the biology of the hepatotoxic bloom forming cyanobacterium Anabaena sp. strain 90

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dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor University of Helsinki, Department of Food and Nutrition en
dc.contributor.author Wang, Hao
dc.contributor.author Sivonen, Kaarina
dc.contributor.author Rouhiainen, Leo A O
dc.contributor.author Fewer, David Peter
dc.contributor.author Lyra, Christina
dc.contributor.author Rantala-Ylinen, Anne
dc.contributor.author Vestola, Johanna
dc.contributor.author Jokela, Jouni
dc.contributor.author Rantasärkkä, Kaisa
dc.contributor.author Li, Zhijie
dc.contributor.author Liu, Bin
dc.date.accessioned 2016-05-31T08:12:01Z
dc.date.available 2016-05-31T08:12:01Z
dc.date.issued 2012
dc.identifier.citation Wang , H , Sivonen , K , Rouhiainen , L A O , Fewer , D P , Lyra , C , Rantala-Ylinen , A , Vestola , J , Jokela , J , Rantasärkkä , K , Li , Z & Liu , B 2012 , ' Genome derived insights into the biology of the hepatotoxic bloom forming cyanobacterium Anabaena sp. strain 90 ' , BMC Genomics , vol. 13 , no. Article No.613 . https://doi.org/10.1186/1471-2164-13-613 en
dc.identifier.issn 1471-2164
dc.identifier.other PURE: 25695469
dc.identifier.other PURE UUID: 599ac252-46a8-4052-ac75-3bb59dc5db4d
dc.identifier.other WOS: 000314647800002
dc.identifier.other Scopus: 84868670393
dc.identifier.other ORCID: /0000-0003-3978-4845/work/40493869
dc.identifier.other ORCID: /0000-0001-7423-7789/work/30281177
dc.identifier.other ORCID: /0000-0001-5096-3575/work/29641931
dc.identifier.other ORCID: /0000-0002-2904-0458/work/40494110
dc.identifier.uri http://hdl.handle.net/10138/163065
dc.description.abstract Background Cyanobacteria can form massive toxic blooms in fresh and brackish bodies of water and are frequently responsible for the poisoning of animals and pose a health risk for humans. Anabaena is a genus of filamentous diazotrophic cyanobacteria commonly implicated as a toxin producer in blooms in aquatic ecosystems throughout the world. The biology of bloom-forming cyanobacteria is poorly understood at the genome level. Results Here, we report the complete sequence and comprehensive annotation of the bloom-forming Anabaena sp. strain 90 genome. It comprises two circular chromosomes and three plasmids with a total size of 5.3 Mb, encoding a total of 4,738 genes. The genome is replete with mobile genetic elements. Detailed manual annotation demonstrated that almost 5% of the gene repertoire consists of pseudogenes. A further 5% of the genome is dedicated to the synthesis of small peptides that are the products of both ribosomal and nonribosomal biosynthetic pathways. Inactivation of the hassallidin (an antifungal cyclic peptide) biosynthetic gene cluster through a deletion event and a natural mutation of the buoyancy-permitting gvpG gas vesicle gene were documented. The genome contains a large number of genes encoding restriction-modification systems. Two novel excision elements were found in the nifH gene that is required for nitrogen fixation. Conclusions Genome analysis demonstrated that this strain invests heavily in the production of bioactive compounds and restriction-modification systems. This well-annotated genome provides a platform for future studies on the ecology and biology of these important bloom-forming cyanobacteria. en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof BMC Genomics
dc.rights en
dc.subject 1183 Plant biology, microbiology, virology en
dc.subject 1184 Genetics, developmental biology, physiology en
dc.title Genome derived insights into the biology of the hepatotoxic bloom forming cyanobacterium Anabaena sp. strain 90 en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1186/1471-2164-13-613
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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