Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

Show full item record



Permalink

http://hdl.handle.net/10138/163189

Citation

Aho , V , Ollila , H M , Kronholm , E , Bondia-Pons , I , Soininen , P , Kangas , A J , Hilvo , M , Seppala , I , Kettunen , J , Oikonen , M , Raitoharju , E , Hyotylainen , T , Kahonen , M , Viikari , J S A , Harma , M , Sallinen , M , Olkkonen , V M , Alenius , H , Jauhiainen , M , Paunio , T , Lehtimaki , T , Salomaa , V , Oresic , M , Raitakari , O T , Ala-Korpela , M & Porkka-Heiskanen , T 2016 , ' Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses ' , Scientific Reports , vol. 6 , 24828 . https://doi.org/10.1038/srep24828

Title: Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
Author: Aho, Vilma; Ollila, Hanna M.; Kronholm, Erkki; Bondia-Pons, Isabel; Soininen, Pasi; Kangas, Antti J.; Hilvo, Mika; Seppala, Ilkka; Kettunen, Johannes; Oikonen, Mervi; Raitoharju, Emma; Hyotylainen, Tuulia; Kahonen, Mika; Viikari, Jorma S. A.; Harma, Mikko; Sallinen, Mikael; Olkkonen, Vesa M.; Alenius, Harri; Jauhiainen, Matti; Paunio, Tiina; Lehtimaki, Terho; Salomaa, Veikko; Oresic, Matej; Raitakari, Olli T.; Ala-Korpela, Mika; Porkka-Heiskanen, Tarja
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Clinicum
University of Helsinki, Medicum
Date: 2016-04-22
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/163189
Abstract: Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
Subject: HIGH-DENSITY-LIPOPROTEIN
CASSETTE TRANSPORTER G1
CORONARY-HEART-DISEASE
ACUTE-PHASE RESPONSE
LIVER-X-RECEPTORS
INSULIN-RESISTANCE
CARDIOVASCULAR RISK
INSUFFICIENT SLEEP
GLUCOSE-METABOLISM
GENERAL-POPULATION
3111 Biomedicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
srep24828.pdf 888.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record