Post-transplant Merkel Cell Carcinoma

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http://hdl.handle.net/10138/163514

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Koljonen , V , Sahi , H , Bohling , T & Mäkisalo , H 2016 , ' Post-transplant Merkel Cell Carcinoma ' , Acta Dermato-Venereologica , vol. 96 , no. 4 , pp. 442-447 . https://doi.org/10.2340/00015555-2284

Title: Post-transplant Merkel Cell Carcinoma
Author: Koljonen, Virve; Sahi, Helka; Bohling, Tom; Mäkisalo, Heikki
Contributor: University of Helsinki, Clinicum
University of Helsinki, Department of Pathology
University of Helsinki, Medicum
University of Helsinki, IV kirurgian klinikka
Date: 2016
Language: eng
Number of pages: 6
Belongs to series: Acta Dermato-Venereologica
ISSN: 0001-5555
URI: http://hdl.handle.net/10138/163514
Abstract: Malignant tumours are the foremost complications of immunosuppressive treatment. They are a major challenge for organ transplant recipients and their treating physicians. This paper reviews the aetiology and current treatment of an unusual neuroendocrine skin cancer, Merkel cell carcinoma (MCC), caused by a Merkel cell polyomavirus infection. MCC occurs more frequently than expected in immunosuppressed subjects, especially in organ transplant recipients. The current literature comprises reports of 79 organ transplant recipients with MCC. The risk of MCC in organ transplant recipients is increased up to 66-182-fold compared with the general population. In addition to the increased risk of developing MCC, immunosuppressed individuals have poorer MCC-specific survival. The aim of this review article is to familiarize organ transplant doctors with this unique and clinically challenging skin cancer, and to provide recent data on the diagnosis and current treatment recommendations for an immunosuppressed population.
Subject: neuroendocrine carcinoma
skin
malignancy
outcome
RENAL-TRANSPLANT RECIPIENTS
T-ANTIGEN
POLYOMAVIRUS
SKIN
DIAGNOSIS
KIDNEY
LUNG
3121 General medicine, internal medicine and other clinical medicine
3122 Cancers
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