Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord : Indirect Evidence of Increased Foetal Activity-A Retrospective Cohort Study

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Kivisto , J , Lehto , S M , Halonen , K , Georgiadis , L & Heinonen , S 2016 , ' Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord : Indirect Evidence of Increased Foetal Activity-A Retrospective Cohort Study ' , PLoS One , vol. 11 , no. 4 , 0154628 . https://doi.org/10.1371/journal.pone.0154628

Title: Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord : Indirect Evidence of Increased Foetal Activity-A Retrospective Cohort Study
Author: Kivisto, Julia; Lehto, Soili M.; Halonen, Katja; Georgiadis, Leena; Heinonen, Seppo
Contributor: University of Helsinki, University of Eastern Finland
University of Helsinki, Clinicum
Date: 2016-04-29
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
URI: http://hdl.handle.net/10138/163558
Abstract: Background Antenatal depression affects up to 19% of pregnant women. Some of these women are also in need of antidepressant treatment. Nevertheless, the impact of maternal antidepressant treatment and prenatal depression on the course of pregnancy, foetal development and delivery outcomes is not fully understood. Methods We analysed data from 24 818 women who gave birth at Kuopio University Hospital between 2002-2012. Logistic regression analysis was used to estimate associations between the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and the progression of pregnancy, development of the foetus and delivery outcomes. Results Altogether, 369 (1.5%) women used SSRIs. A regression model adjusted for age, overweight, nulliparity, prior termination, miscarriages, smoking, maternal alcohol consumption, chronic illness and polyhydramnion showed that pregnant women exposed to SSRI medication had significantly lower Apgar scores at 1 minute (p <0.0001) and 5 minutes (p <0.0001) and more admissions to the neonatal intensive care unit (p <0.0001) than unexposed pregnant women. In addition, exposed newborns had longer umbilical cords (p <0.0001) than non-exposed newborns. Conclusion In addition to the previously known associates with maternal SSRI exposure, such as lowered Apgar scores, SSRI exposure appeared to be associated with increased umbilical cord length. The observation related to increased umbilical cord length may be explained by an SSRI-induced increase in the movements of the developing foetus.
Subject: IN-UTERO EXPOSURE
NEONATAL OUTCOMES
PREGNANCY
DEPRESSION
ANTIDEPRESSANTS
PREVALENCE
GROWTH
IMPACT
RISK
TERM
3123 Gynaecology and paediatrics
3124 Neurology and psychiatry
515 Psychology
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