Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2 '-deoxyguanosine and Nitrotyrosine in Melanoma

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Hintsala , H-R , Jokinen , E , Haapasaari , K-M , Moza , M , Ristimaki , A , Soini , Y , Koivunen , J & Karihtala , P 2016 , ' Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2 '-deoxyguanosine and Nitrotyrosine in Melanoma ' , Anticancer Research , vol. 36 , no. 4 , pp. 1497-1506 . < http://ar.iiarjournals.org/content/36/4/1497.short >

Title: Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2 '-deoxyguanosine and Nitrotyrosine in Melanoma
Author: Hintsala, Hanna-Riikka; Jokinen, Elina; Haapasaari, Kirsi-Maria; Moza, Monica; Ristimaki, Ari; Soini, Ylermi; Koivunen, Jussi; Karihtala, Peeter
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
Date: 2016-04
Language: eng
Number of pages: 10
Belongs to series: Anticancer Research
ISSN: 0250-7005
URI: http://hdl.handle.net/10138/163560
Abstract: Background/Aim: Increased expression and prognostic significance of major redox regulator nuclear factor erythroid-2-related factor (Nrf2) is recognized in many cancers. Our aim was to investigate the role of oxidative stress markers in melanoma. Materials and Methods: We characterized the immunohistochemical expression of Nrf2, kelch-like ECH-associated protein 1 (Keap1), BRAF(V600E), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and nitrotyrosine in 36 nevi, 14 lentigo maligna and 71 malignant melanomas. We measured Nrf2 expression in melanoma cell lines and conducted cytotoxicity assays combining BRAF/NRAS ablation and H2O2 treatment. Results: Nuclear Nrf2 expression in melanoma correlated with deeper Breslow (p
Subject: BRAF
Keap1
melanoma
nitrotyrosine
Nrf2
oxidative stress
8-OHdG
CLINICOPATHOLOGICAL FEATURES
NRF2 EXPRESSION
POOR SURVIVAL
CANCER
8-HYDROXYDEOXYGUANOSINE
CARCINOGENESIS
DAMAGE
MICROENVIRONMENT
INHIBITOR
3122 Cancers
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