Use of anti-dementia drugs in home care and residential care and associations with neuropsychiatric symptoms : a cross-sectional study

Show simple item record

dc.contributor.author Kuronen, Marja
dc.contributor.author Koponen, Hannu
dc.contributor.author Nykanen, Irma
dc.contributor.author Karppi, Pertti
dc.contributor.author Hartikainen, Sirpa
dc.date.accessioned 2016-06-17T09:09:01Z
dc.date.available 2016-06-17T09:09:01Z
dc.date.issued 2015-08-13
dc.identifier.citation Kuronen , M , Koponen , H , Nykanen , I , Karppi , P & Hartikainen , S 2015 , ' Use of anti-dementia drugs in home care and residential care and associations with neuropsychiatric symptoms : a cross-sectional study ' , BMC Geriatrics , vol. 15 , 100 . https://doi.org/10.1186/s12877-015-0102-4
dc.identifier.other PURE: 53118810
dc.identifier.other PURE UUID: 5703d08c-8be4-4b98-b0a3-b66151c70da2
dc.identifier.other WOS: 000359337800001
dc.identifier.other Scopus: 84938917807
dc.identifier.other ORCID: /0000-0002-7368-1869/work/29942611
dc.identifier.uri http://hdl.handle.net/10138/164079
dc.description.abstract Background: The number of people with dementia is increasing alongside the aging population, and most of these patients manifest with neuropsychiatric symptoms (NPS). The objective of this study was to investigate anti-dementia drug use and its associations with NPS. Methods: Questionnaires on demographic information, current drug use, activities of daily living and NPS were sent to all municipal home care producers and to all institutions providing long-term residential care in the South Savo Hospital District, Finland. Results: The study population comprised 2821 persons. Their mean age was 81 years and 68 % were female. Dementia had been diagnosed in 31 % (n = 410) in home care and in 56 % (n = 774) in residential care. Anti-dementia drugs were used by 69 % of patients with dementia. Hyperactivity symptoms were common in residential care patients (n = 456, 33 %), while problems with mood and apathy dominated in home care patients (n = 486, 54 %). In multivariate regression analysis, the mood symptoms and apathy subgroup was associated with use of an acetylcholinesterase inhibitor (AChEI) (OR 1.44; 95 % Cl 1.03-2.02), memantine (OR 1.77, 95 % Cl 1.15-2.72) or their combinations (OR 1.56, 95 % Cl 1.03-2.34). Hyperactivity symptoms were associated with combination therapy of this type (OR 2.03, 95 % Cl 1.36-2.34). Conclusions: The use of anti-dementia drugs was common in both care settings. The use of any anti-dementia drug or combination was associated with the mood and apathy subgroup. The hyperactivity subgroup was associated with combination use of memantine and AChEI. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof BMC Geriatrics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject SEVERE ALZHEIMERS-DISEASE
dc.subject PSYCHOLOGICAL SYMPTOMS
dc.subject BEHAVIORAL-PROBLEMS
dc.subject GERIATRIC CARE
dc.subject OLD-PEOPLE
dc.subject DEMENTIA
dc.subject MANAGEMENT
dc.subject CONSORTIUM
dc.subject MEMANTINE
dc.subject MODERATE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Use of anti-dementia drugs in home care and residential care and associations with neuropsychiatric symptoms : a cross-sectional study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Psychiatry
dc.contributor.organization HUS Psychiatry
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s12877-015-0102-4
dc.relation.issn 1471-2318
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
s12877_015_0102_4.pdf 441.9Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record