Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis

Show simple item record Sobral-Leite, Marcelo Wesseling, Jelle Smit, Vincent T. H. B. M. Nevanlinna, Heli van Miltenburg, Martine H. Sanders, Joyce Hofland, Ingrid Blows, Fiona M. Coulson, Penny Patrycja, Gazinska Schellens, Jan H. M. Fagerholm, Rainer Heikkila, Paivi Aittomaki, Kristiina Blomqvist, Carl Provenzano, Elena Ali, Hamid Raza Figueroa, Jonine Sherman, Mark Lissowska, Jolanta Mannermaa, Arto Kataja, Vesa Kosma, Veli-Matti Hartikainen, Jaana M. Phillips, Kelly-Anne Couch, Fergus J. Olson, Janet E. Vachon, Celine Visscher, Daniel Brenner, Hermann Butterbach, Katja Arndt, Volker Holleczek, Bernd Hooning, Maartje J. Hollestelle, Antoinette Martens, John W. M. van Deurzen, Carolien H. M. van de Water, Bob Broeks, Annegien Chang-Claude, Jenny Chenevix-Trench, Georgia Easton, Douglas F. Pharoah, Paul D. P. Garcia-Closas, Montserrat de Graauw, Marjo Schmidt, Marjanka K. kConFab-AOCS Investigators 2016-06-17T12:42:02Z 2016-06-17T12:42:02Z 2015-07-02
dc.identifier.citation Sobral-Leite , M , Wesseling , J , Smit , V T H B M , Nevanlinna , H , van Miltenburg , M H , Sanders , J , Hofland , I , Blows , F M , Coulson , P , Patrycja , G , Schellens , J H M , Fagerholm , R , Heikkila , P , Aittomaki , K , Blomqvist , C , Provenzano , E , Ali , H R , Figueroa , J , Sherman , M , Lissowska , J , Mannermaa , A , Kataja , V , Kosma , V-M , Hartikainen , J M , Phillips , K-A , Couch , F J , Olson , J E , Vachon , C , Visscher , D , Brenner , H , Butterbach , K , Arndt , V , Holleczek , B , Hooning , M J , Hollestelle , A , Martens , J W M , van Deurzen , C H M , van de Water , B , Broeks , A , Chang-Claude , J , Chenevix-Trench , G , Easton , D F , Pharoah , P D P , Garcia-Closas , M , de Graauw , M , Schmidt , M K & kConFab-AOCS Investigators 2015 , ' Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis ' , BMC Medicine , vol. 13 , 156 .
dc.identifier.other PURE: 52120037
dc.identifier.other PURE UUID: a64787e3-4016-40f0-adbb-fb66b4b572b8
dc.identifier.other WOS: 000357312000001
dc.identifier.other Scopus: 84935085249
dc.description.abstract Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof BMC Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Breast cancer
dc.subject Annexin A1
dc.subject BRCA1 and BRCA2 mutations
dc.subject GROWTH-FACTOR
dc.subject CELLS
dc.subject METASTASIS
dc.subject SURVIVAL
dc.subject COMPLEX
dc.subject 3122 Cancers
dc.subject 3123 Gynaecology and paediatrics
dc.title Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis en
dc.type Article
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization Clinicum
dc.contributor.organization Department of Pathology
dc.contributor.organization Medicum
dc.contributor.organization Kristiina Aittomäki / Principal Investigator
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization Department of Oncology
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1741-7015
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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