Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis

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dc.contributor.author Sobral-Leite, Marcelo
dc.contributor.author Wesseling, Jelle
dc.contributor.author Smit, Vincent T. H. B. M.
dc.contributor.author Nevanlinna, Heli
dc.contributor.author van Miltenburg, Martine H.
dc.contributor.author Sanders, Joyce
dc.contributor.author Hofland, Ingrid
dc.contributor.author Blows, Fiona M.
dc.contributor.author Coulson, Penny
dc.contributor.author Patrycja, Gazinska
dc.contributor.author Schellens, Jan H. M.
dc.contributor.author Fagerholm, Rainer
dc.contributor.author Heikkila, Paivi
dc.contributor.author Aittomaki, Kristiina
dc.contributor.author Blomqvist, Carl
dc.contributor.author Provenzano, Elena
dc.contributor.author Ali, Hamid Raza
dc.contributor.author Figueroa, Jonine
dc.contributor.author Sherman, Mark
dc.contributor.author Lissowska, Jolanta
dc.contributor.author Mannermaa, Arto
dc.contributor.author Kataja, Vesa
dc.contributor.author Kosma, Veli-Matti
dc.contributor.author Hartikainen, Jaana M.
dc.contributor.author Phillips, Kelly-Anne
dc.contributor.author Couch, Fergus J.
dc.contributor.author Olson, Janet E.
dc.contributor.author Vachon, Celine
dc.contributor.author Visscher, Daniel
dc.contributor.author Brenner, Hermann
dc.contributor.author Butterbach, Katja
dc.contributor.author Arndt, Volker
dc.contributor.author Holleczek, Bernd
dc.contributor.author Hooning, Maartje J.
dc.contributor.author Hollestelle, Antoinette
dc.contributor.author Martens, John W. M.
dc.contributor.author van Deurzen, Carolien H. M.
dc.contributor.author van de Water, Bob
dc.contributor.author Broeks, Annegien
dc.contributor.author Chang-Claude, Jenny
dc.contributor.author Chenevix-Trench, Georgia
dc.contributor.author Easton, Douglas F.
dc.contributor.author Pharoah, Paul D. P.
dc.contributor.author Garcia-Closas, Montserrat
dc.contributor.author de Graauw, Marjo
dc.contributor.author Schmidt, Marjanka K.
dc.contributor.author kConFab-AOCS Investigators
dc.date.accessioned 2016-06-17T12:42:02Z
dc.date.available 2016-06-17T12:42:02Z
dc.date.issued 2015-07-02
dc.identifier.citation Sobral-Leite , M , Wesseling , J , Smit , V T H B M , Nevanlinna , H , van Miltenburg , M H , Sanders , J , Hofland , I , Blows , F M , Coulson , P , Patrycja , G , Schellens , J H M , Fagerholm , R , Heikkila , P , Aittomaki , K , Blomqvist , C , Provenzano , E , Ali , H R , Figueroa , J , Sherman , M , Lissowska , J , Mannermaa , A , Kataja , V , Kosma , V-M , Hartikainen , J M , Phillips , K-A , Couch , F J , Olson , J E , Vachon , C , Visscher , D , Brenner , H , Butterbach , K , Arndt , V , Holleczek , B , Hooning , M J , Hollestelle , A , Martens , J W M , van Deurzen , C H M , van de Water , B , Broeks , A , Chang-Claude , J , Chenevix-Trench , G , Easton , D F , Pharoah , P D P , Garcia-Closas , M , de Graauw , M , Schmidt , M K & kConFab-AOCS Investigators 2015 , ' Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis ' , BMC Medicine , vol. 13 , 156 . https://doi.org/10.1186/s12916-015-0392-6
dc.identifier.other PURE: 52120037
dc.identifier.other PURE UUID: a64787e3-4016-40f0-adbb-fb66b4b572b8
dc.identifier.other WOS: 000357312000001
dc.identifier.other Scopus: 84935085249
dc.identifier.uri http://hdl.handle.net/10138/164124
dc.description.abstract Background: Annexin A1 (ANXA1) is a protein related with the carcinogenesis process and metastasis formation in many tumors. However, little is known about the prognostic value of ANXA1 in breast cancer. The purpose of this study is to evaluate the association between ANXA1 expression, BRCA1/2 germline carriership, specific tumor subtypes and survival in breast cancer patients. Methods: Clinical-pathological information and follow-up data were collected from nine breast cancer studies from the Breast Cancer Association Consortium (BCAC) (n = 5,752) and from one study of familial breast cancer patients with BRCA1/2 mutations (n = 107). ANXA1 expression was scored based on the percentage of immunohistochemical staining in tumor cells. Survival analyses were performed using a multivariable Cox model. Results: The frequency of ANXA1 positive tumors was higher in familial breast cancer patients with BRCA1/2 mutations than in BCAC patients, with 48.6 % versus 12.4 %, respectively; P <0.0001. ANXA1 was also highly expressed in BCAC tumors that were poorly differentiated, triple negative, EGFR-CK5/6 positive or had developed in patients at a young age. In the first 5 years of follow-up, patients with ANXA1 positive tumors had a worse breast cancer-specific survival (BCSS) than ANXA1 negative (HRadj = 1.35; 95 % CI = 1.05-1.73), but the association weakened after 10 years (HRadj = 1.13; 95 % CI = 0.91-1.40). ANXA1 was a significant independent predictor of survival in HER2+ patients (10-years BCSS: HRadj = 1.70; 95 % CI = 1.17-2.45). Conclusions: ANXA1 is overexpressed in familial breast cancer patients with BRCA1/2 mutations and correlated with poor prognosis features: triple negative and poorly differentiated tumors. ANXA1 might be a biomarker candidate for breast cancer survival prediction in high risk groups such as HER2+ cases. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof BMC Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Breast cancer
dc.subject Annexin A1
dc.subject BRCA1 and BRCA2 mutations
dc.subject GROWTH-FACTOR
dc.subject PROTEIN-KINASE
dc.subject CELLS
dc.subject PHOSPHORYLATION
dc.subject CHEMOTHERAPY
dc.subject METASTASIS
dc.subject SURVIVAL
dc.subject COMPLEX
dc.subject DIFFERENTIATION
dc.subject ADENOCARCINOMA
dc.subject 3122 Cancers
dc.subject 3123 Gynaecology and paediatrics
dc.title Annexin A1 expression in a pooled breast cancer series : association with tumor subtypes and prognosis en
dc.type Article
dc.contributor.organization Department of Obstetrics and Gynecology
dc.contributor.organization Clinicum
dc.contributor.organization Department of Pathology
dc.contributor.organization Medicum
dc.contributor.organization Kristiina Aittomäki / Principal Investigator
dc.contributor.organization Department of Medical and Clinical Genetics
dc.contributor.organization Department of Oncology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s12916-015-0392-6
dc.relation.issn 1741-7015
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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