Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients : a cohort study

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http://hdl.handle.net/10138/164127

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Romaguera , D , Ward , H , Wark , P A , Vergnaud , A-C , Peeters , P H , van Gils , C H , Ferrari , P , Fedirko , V , Jenab , M , Boutron-Ruault , M-C , Dossus , L , Dartois , L , Hansen , C P , Dahm , C C , Buckland , G , Sanchez , M J , Dorronsoro , M , Navarro , C , Barricarte , A , Key , T J , Trichopoulou , A , Tsironis , C , Lagiou , P , Masala , G , Pala , V , Tumino , R , Vineis , P , Panico , S , Bueno-de-Mesquita , H B , Siersema , P D , Ohlsson , B , Jirstrom , K , Wennberg , M , Nilsson , L M , Weiderpass , E , Kuehn , T , Katzke , V , Khaw , K-T , Wareham , N J , Tjonneland , A , Boeing , H , Quiros , J R , Gunter , M J , Riboli , E & Norat , T 2015 , ' Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients : a cohort study ' BMC Medicine , vol. 13 , 107 . DOI: 10.1186/s12916-015-0332-5

Title: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients : a cohort study
Author: Romaguera, Dora; Ward, Heather; Wark, Petra A.; Vergnaud, Anne-Claire; Peeters, Petra H.; van Gils, Carla H.; Ferrari, Pietro; Fedirko, Veronika; Jenab, Mazda; Boutron-Ruault, Marie-Christine; Dossus, Laure; Dartois, Laureen; Hansen, Camilla Plambeck; Dahm, Christina Catherine; Buckland, Genevieve; Sanchez, Maria Jose; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; Key, Timothy J.; Trichopoulou, Antonia; Tsironis, Christos; Lagiou, Pagona; Masala, Giovanna; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Siersema, Peter D.; Ohlsson, Bodil; Jirstrom, Karin; Wennberg, Maria; Nilsson, Lena M.; Weiderpass, Elisabete; Kuehn, Tilman; Katzke, Verena; Khaw, Kay-Tee; Wareham, Nick J.; Tjonneland, Anne; Boeing, Heiner; Quiros, Jose R.; Gunter, Marc J.; Riboli, Elio; Norat, Teresa
Contributor: University of Helsinki, Department of Medical and Clinical Genetics
Date: 2015-05-07
Language: eng
Number of pages: 12
Belongs to series: BMC Medicine
ISSN: 1741-7015
URI: http://hdl.handle.net/10138/164127
Abstract: Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.
Subject: Colorectal cancer
Diet
Healthy lifestyle
Physical activity
Survival
Weight
BODY-MASS INDEX
RESEARCH FUND/AMERICAN INSTITUTE
RECREATIONAL PHYSICAL-ACTIVITY
LIFE-STYLE FACTORS
BREAST-CANCER
REPRODUCTIVE HISTORY
COLON-CANCER
RISK
NUTRITION
DIAGNOSIS
3122 Cancers
3121 Internal medicine
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