Genetic predisposition to acute kidney injury - a systematic review

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Vilander , L M , Kaunisto , M A & Pettila , V 2015 , ' Genetic predisposition to acute kidney injury - a systematic review ' , BMC Nephrology , vol. 16 , 197 . https://doi.org/10.1186/s12882-015-0190-6

Title: Genetic predisposition to acute kidney injury - a systematic review
Author: Vilander, Laura M.; Kaunisto, Mari A.; Pettila, Ville
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Clinicum
Date: 2015-12-02
Language: eng
Number of pages: 10
Belongs to series: BMC Nephrology
ISSN: 1471-2369
URI: http://hdl.handle.net/10138/164209
Abstract: Background: The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic predisposition to AKI or outcome of AKI patients. Methods: We searched Ovid SP (MEDLINE) and EMBASE databases and found 4027 references to AKI. Based on titles and abstracts, we approved 37 articles for further analysis. Nine were published only as abstracts, leaving 28 original articles in the final analysis. We extracted the first author, year of publication, study design, clinical setting, number of studied patients, patients with AKI, ethnicity of patients, studied polymorphisms, endpoints, AKI definition, phenotype, significant findings, and data for quality scoring from each article. We summarized the findings and scored the quality of articles. Results: The articles were quite heterogeneous and of moderate quality (mean 6.4 of 10). Conclusions: Despite different gene polymorphisms with suggested associations with development or severity or outcome of AKI, definitive conclusions would require replication of associations in independent cohort studies and, preferably a hypothesis-free study design.
Subject: Acute kidney injury
Genetic variation
Genetic polymorphism
CRITICALLY-ILL PATIENTS
APOLIPOPROTEIN-E POLYMORPHISM
NECROSIS-FACTOR-ALPHA
ACUTE-RENAL-FAILURE
GENOME-WIDE ASSOCIATION
CARDIAC-SURGERY
PROMOTER POLYMORPHISM
ADVERSE OUTCOMES
RIFLE CRITERIA
RISK
3126 Surgery, anesthesiology, intensive care, radiology
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