Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction

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dc.contributor.author Ilumets, Helen
dc.contributor.author Mazur, Witold
dc.contributor.author Toljamo, Tuula
dc.contributor.author Louhelainen, Noora
dc.contributor.author Nieminen, Pentti
dc.contributor.author Kobayashi, Hideo
dc.contributor.author Ishikawa, Nobuhisa
dc.contributor.author Kinnula, Vuokko L.
dc.date.accessioned 2016-06-20T12:10:02Z
dc.date.available 2016-06-20T12:10:02Z
dc.date.issued 2011
dc.identifier.citation Ilumets , H , Mazur , W , Toljamo , T , Louhelainen , N , Nieminen , P , Kobayashi , H , Ishikawa , N & Kinnula , V L 2011 , ' Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction ' , BMC Pulmonary Medicine , vol. 11 , 19 . https://doi.org/10.1186/1471-2466-11-19
dc.identifier.other PURE: 56194033
dc.identifier.other PURE UUID: bc40c708-aa71-4d23-8037-2623040e1fde
dc.identifier.other WOS: 000208592800019
dc.identifier.other Scopus: 79955113393
dc.identifier.uri http://hdl.handle.net/10138/164318
dc.description.abstract Background: A significant number of young people start smoking at an age of 13-15, which means that serious smoking-evoked changes may have been occurred by their twenties. Surfactant proteins (SP) and matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been linked to cigarette smoke induced lung remodelling and chronic obstructive pulmonary disease (COPD). However, the level of these proteins has not been examined during ageing or in young individuals with short smoking histories. Methods: Plasma levels of SP-A, SP-D, MMP-9, and TIMP-1 were measured by EIA/ELISA from young (18-23 years) non-smoking controls (YNS) (n = 36), smokers (YS) (n = 51), middle aged/elderly (37-77 years) non-smoking controls (ONS) (n = 40), smokers (OS) (n = 64) (FEV1/FVC >0.7 in all subjects) and patients with COPD (n = 44, 35-79 years). Results: Plasma levels of SP-A increased with age and in the older group in relation to smoking and COPD. Plasma SP-D and MMP-9 levels did not change with age but were elevated in OS and COPD as compared to ONS. The TIMP-1 level declined with age but increased in chronic smokers when compared to ONS. The clearest correlations could be detected between plasma SP-A vs. age, pack years and FEV1/FVC. The receiver operating characteristic (ROC) curve analysis revealed SP-A to be the best marker for discriminating between patients with COPD and the controls (area under ROC curve of 0.842; 95% confidence interval, 0.785-0.899; p <0.001). Conclusions: Age has a significant contribution to potential markers related to smoking and COPD; SP-A seems to be the best factor in differentiating COPD from the controls. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof BMC Pulmonary Medicine
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction en
dc.type Article
dc.contributor.organization Department of Medicine
dc.contributor.organization Keuhkosairauksien yksikkö
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/1471-2466-11-19
dc.relation.issn 1471-2466
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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