Genetic and environmental influences on height from infancy to early adulthood : An individual-based pooled analysis of 45 twin cohorts

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Jelenkovic , A , Sund , R , Hur , Y-M , Yokoyama , Y , Hjelmborg , J V B , Moller , S , Honda , C , Magnusson , P K E , Pedersen , N L , Ooki , S , Aaltonen , S , Stazi , M A , Fagnani , C , D'Ippolito , C , Freitas , D L , Maia , J A , Ji , F , Ning , F , Pang , Z , Rebato , E , Busjahn , A , Kandler , C , Saudino , K J , Jang , K L , Cozen , W , Hwang , A E , Mack , T M , Gao , W , Yu , C , Li , L , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Heikkila , K , Wardle , J , Llewellyn , C H , Fisher , A , McAdams , T A , Eley , T C , Gregory , A M , He , M , Ding , X , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Tarnoki , A D , Tarnoki , D L , Knafo-Noam , A , Mankuta , D , Abramson , L , Burt , S A , Klump , K L , Silberg , J L , Eaves , L J , Maes , H H , Krueger , R F , McGue , M , Pahlen , S , Gatz , M , Butler , D A , Bartels , M , van Beijsterveldt , T C E M , Craig , J M , Saffery , R , Dubois , L , Boivin , M , Brendgen , M , Dionne , G , Vitaro , F , Martin , N G , Medland , S E , Montgomery , G W , Swan , G E , Krasnow , R , Tynelius , P , Lichtenstein , P , Haworth , C M A , Plomin , R , Bayasgalan , G , Narandalai , D , Harden , K P , Tucker-Drob , E M , Spector , T , Mangino , M , Lachance , G , Baker , L A , Tuvblad , C , Duncan , G E , Buchwald , D , Willemsen , G , Skytthe , A , Kyvik , K O , Christensen , K , Oncel , S Y , Aliev , F , Rasmussen , F , Goldberg , J H , Sorensen , T I A , Boomsma , D I , Kaprio , J & Silventoinen , K 2016 , ' Genetic and environmental influences on height from infancy to early adulthood : An individual-based pooled analysis of 45 twin cohorts ' , Scientific Reports , vol. 6 , 28496 . https://doi.org/10.1038/srep28496

Title: Genetic and environmental influences on height from infancy to early adulthood : An individual-based pooled analysis of 45 twin cohorts
Author: Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi; Yokoyama, Yoshie; Hjelmborg, Jacob V. B.; Moller, Soren; Honda, Chika; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ooki, Syuichi; Aaltonen, Sari; Stazi, Maria A.; Fagnani, Corrado; D'Ippolito, Cristina; Freitas, Duarte L.; Maia, Jose Antonio; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Busjahn, Andreas; Kandler, Christian; Saudino, Kimberly J.; Jang, Kerry L.; Cozen, Wendy; Hwang, Amie E.; Mack, Thomas M.; Gao, Wenjing; Yu, Canqing; Li, Liming; Corley, Robin P.; Huibregtse, Brooke M.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Heikkila, Kauko; Wardle, Jane; Llewellyn, Clare H.; Fisher, Abigail; McAdams, Tom A.; Eley, Thalia C.; Gregory, Alice M.; He, Mingguang; Ding, Xiaohu; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D.; Tarnoki, David L.; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Burt, S. Alexandra; Klump, Kelly L.; Silberg, Judy L.; Eaves, Lindon J.; Maes, Hermine H.; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A.; Bartels, Meike; van Beijsterveldt, Toos C. E. M.; Craig, Jeffrey M.; Saffery, Richard; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Swan, Gary E.; Krasnow, Ruth; Tynelius, Per; Lichtenstein, Paul; Haworth, Claire M. A.; Plomin, Robert; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Harden, K. Paige; Tucker-Drob, Elliot M.; Spector, Timothy; Mangino, Massimo; Lachance, Genevieve; Baker, Laura A.; Tuvblad, Catherine; Duncan, Glen E.; Buchwald, Dedra; Willemsen, Gonneke; Skytthe, Axel; Kyvik, Kirsten O.; Christensen, Kaare; Oncel, Sevgi Y.; Aliev, Fazil; Rasmussen, Finn; Goldberg, Jack H.; Sorensen, Thorkild I. A.; Boomsma, Dorret I.; Kaprio, Jaakko; Silventoinen, Karri
Contributor organization: Department of Social Research (2010-2017)
Department of Public Health
Clinicum
Jaakko Kaprio / Principal Investigator
Institute for Molecular Medicine Finland
Sociology
Center for Population, Health and Society
Population Research Unit (PRU)
Genetic Epidemiology
Date: 2016-06-23
Language: eng
Number of pages: 13
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/srep28496
URI: http://hdl.handle.net/10138/164758
Abstract: Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.
Subject: BODY-MASS INDEX
GENOME-WIDE ASSOCIATION
CODATWINS PROJECT
GROWTH
HERITABILITY
CHILDHOOD
TRAITS
WEIGHT
AGE
POPULATIONS
3142 Public health care science, environmental and occupational health
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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