Maternal drug or alcohol abuse is associated with decreased head size frommid-pregnancy to childhood

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Lehikoinen , A , Orden , M-R , Heinonen , S T & Voutilainen , R 2016 , ' Maternal drug or alcohol abuse is associated with decreased head size frommid-pregnancy to childhood ' , Acta Paediatrica , vol. 105 , no. 7 , pp. 817-822 . https://doi.org/10.1111/apa.13416

Title: Maternal drug or alcohol abuse is associated with decreased head size frommid-pregnancy to childhood
Author: Lehikoinen, Anni; Orden, Maija-Riitta; Heinonen, Seppo Tapani; Voutilainen, Raimo
Contributor: University of Helsinki, Clinicum
Date: 2016-07
Language: eng
Number of pages: 6
Belongs to series: Acta Paediatrica
ISSN: 0803-5253
URI: http://hdl.handle.net/10138/164841
Abstract: AimMaternal alcohol abuse is poorly recognised and causes developmental problems. This study explored the foetal central nervous systems (CNS), head circumference and psychomotor development of children exposed to drugs or alcohol during pregnancy up to 2.5years of age. MethodsWe recruited 23 pregnant women referred to Kuopio University Hospital, Finland, by their family doctor because of drug or alcohol abuse, and 22 control mothers. Foetal CNS parameters were measured by three-dimensional ultrasonography at the mean gestational age of 20weeks and the Griffiths Mental Developmental Scales (GMDS), and anthropometric measurements were carried out at the mean ages of one and 2.5years. ResultsThe exposed foetuses had decreased biparietal and occipito-frontal distances and head circumferences, but unchanged cerebellar volume at 20weeks, and decreased head circumferences and length and height at birth, one and 2.5years of age. They scored lower than the controls on the GMDS general quotient and the hearing, language and locomotor subscales at 2.5years of age. ConclusionMaternal alcohol or drug exposure was associated with decreased head size from mid-pregnancy to childhood and reduced development at 2.5years. Foetal head circumference at mid-pregnancy was a useful indicator of substance abuse affecting theCNS.
Subject: Foetal alcohol spectrum disorders
Griffiths Mental Developmental Scales
Head circumference
Three-dimensional imaging
Ultrasound
SPECTRUM DISORDERS
IN-UTERO
EXPOSURE
CHILDREN
CIRCUMFERENCE
BRAIN
BIRTH
SUBSTANCES
FEATURES
INFANTS
3123 Gynaecology and paediatrics
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