Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort : data from the CERERRA collaboration

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dc.contributor.author Chatzidionysiou, Katerina
dc.contributor.author Lie, Elisabeth
dc.contributor.author Nasonov, Evgeny
dc.contributor.author Lukina, Galina
dc.contributor.author Hetland, Merete Lund
dc.contributor.author Tarp, Ulrik
dc.contributor.author Ancuta, Ioan
dc.contributor.author Pavelka, Karel
dc.contributor.author Nordstrom, Dan C.
dc.contributor.author Gabay, Cem
dc.contributor.author Canhao, Helene
dc.contributor.author Tomsic, Matija
dc.contributor.author van Riel, Piet L. C. M.
dc.contributor.author Gomez-Reino, Juan
dc.contributor.author Kvien, Tore K.
dc.contributor.author van Vollenhoven, Ronald F.
dc.contributor.author Rheumatic Dis Portuguese Register
dc.date.accessioned 2016-07-27T07:14:01Z
dc.date.available 2016-07-27T07:14:01Z
dc.date.issued 2016-02-16
dc.identifier.citation Chatzidionysiou , K , Lie , E , Nasonov , E , Lukina , G , Hetland , M L , Tarp , U , Ancuta , I , Pavelka , K , Nordstrom , D C , Gabay , C , Canhao , H , Tomsic , M , van Riel , P L C M , Gomez-Reino , J , Kvien , T K , van Vollenhoven , R F & Rheumatic Dis Portuguese Register 2016 , ' Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort : data from the CERERRA collaboration ' , Arthritis research & therapy , vol. 18 , 50 . https://doi.org/10.1186/s13075-016-0951-z
dc.identifier.other PURE: 60951597
dc.identifier.other PURE UUID: 1dfdc0d3-70d6-4b0d-b479-3601d7c57b73
dc.identifier.other WOS: 000370315400001
dc.identifier.other Scopus: 84957991509
dc.identifier.uri http://hdl.handle.net/10138/164978
dc.description.abstract Background: The approved dose of rituximab (RTX) in rheumatoid arthritis is 1000 mg x 2, but some data have suggested similar clinical efficacy with 500 mg x 2. The purpose of this study was to compare the effectiveness of the regular and low doses given as first treatment course. Methods: Twelve European registries participating in the CERERRA collaboration (The European Collaborative Registries for the Evaluation of Rituximab in Rheumatoid Arthritis) submitted anonymized datasets with demographic, efficacy and treatment data for patients who had started RTX. Treatment effectiveness was assessed by DAS28 reductions and EULAR responses after 6 months. Results: Data on RTX dose were available for 2,873 patients, of whom 2,625 (91.4 %) and 248 (8.6 %) received 1000 mg x 2 and 500 mg x 2, respectively. Patients treated with 500 mg x 2 were significantly older, had longer disease duration, higher number of prior DMARDs, but lower number of prior biologics and lower baseline DAS28 than those treated with 1000 mg x 2. Fewer patients in the low-dose group received concomitant DMARDs but more frequently received concomitant corticosteroids. Both doses led to significant clinical improvements at 6 months. DAS28 reductions at 6 months were comparable in the 2 dose regimens [mean DeltaDAS28 +/- SD -2.0 +/- 1.3 (high dose) vs. -1.7 +/- 1.4 (low dose), p = 0.23 adjusted for baseline differences]. Similar percentages of patients achieved EULAR good response in the two dose groups, 18.4 % vs. 17.3 %, respectively (p = 0.36). Conclusions: In this large observational cohort initial treatment with RTX at 500 mg x 2 and 1000 mg x 2 led to comparable clinical outcomes at 6 months. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Arthritis research & therapy
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Rituximab
dc.subject Rheumatoid arthritis
dc.subject Observational
dc.subject MONOCLONAL-ANTIBODY
dc.subject PLUS METHOTREXATE
dc.subject CONTROLLED-TRIAL
dc.subject JOINT DAMAGE
dc.subject DOUBLE-BLIND
dc.subject EFFICACY
dc.subject SAFETY
dc.subject DEPLETION
dc.subject THERAPY
dc.subject INHIBITION
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Effectiveness of two different doses of rituximab for the treatment of rheumatoid arthritis in an international cohort : data from the CERERRA collaboration en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s13075-016-0951-z
dc.relation.issn 1478-6354
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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