The Three Subtypes of Tick-Borne Encephalitis Virus Induce Encephalitis in a Natural Host, the Bank Vole (Myodes glareolus)

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dc.contributor University of Helsinki, Haartman Institute en
dc.contributor University of Helsinki, Departments of Faculty of Veterinary Medicine en
dc.contributor University of Helsinki, Department of Virology en
dc.contributor University of Helsinki, Haartman Institute en
dc.contributor University of Helsinki, Haartman Institute en
dc.contributor.author Tonteri, Elina
dc.contributor.author Kipar, Anja
dc.contributor.author Voutilainen, Liina
dc.contributor.author Vene, Sirkka
dc.contributor.author Vaheri, Antti
dc.contributor.author Vapalahti, Olli Pekka
dc.contributor.author Lundkvist, Åke
dc.date.accessioned 2016-08-01T12:58:01Z
dc.date.available 2016-08-01T12:58:01Z
dc.date.issued 2013-12-13
dc.identifier.citation Tonteri , E , Kipar , A , Voutilainen , L , Vene , S , Vaheri , A , Vapalahti , O P & Lundkvist , Å 2013 , ' The Three Subtypes of Tick-Borne Encephalitis Virus Induce Encephalitis in a Natural Host, the Bank Vole (Myodes glareolus) ' , PLoS One , vol. 8 , no. 12 , e81214 . https://doi.org/10.1371/journal.pone.0081214 en
dc.identifier.issn 1932-6203
dc.identifier.other PURE: 34005320
dc.identifier.other PURE UUID: 0dabfdb7-1fb9-4e71-845e-c150baef5e43
dc.identifier.other WOS: 000328734200006
dc.identifier.other Scopus: 84892633239
dc.identifier.other ORCID: /0000-0003-2270-6824/work/29926986
dc.identifier.uri http://hdl.handle.net/10138/165061
dc.description.abstract Tick-borne encephalitis virus (TBEV) infects bank voles (Myodes glareolus) in nature, but the relevance of rodents for TBEV transmission and maintenance is unclear. We infected colonized bank voles subcutaneously to study and compare the infection kinetics, acute infection, and potential viral persistence of the three known TBEV subtypes: European (TBEV-Eur), Siberian (TBEV-Sib) and Far Eastern (TBEV-FE). All strains representing the three subtypes were infective and highly neurotropic. They induced (meningo)encephalitis in some of the animals, however most of the cases did not present with apparent clinical symptoms. TBEV-RNA was cleared significantly slower from the brain as compared to other organs studied. Supporting our earlier findings in natural rodent populations, TBEV-RNA could be detected in the brain for up to 168 days post infection, but we could not demonstrate infectivity by cell culture isolation. Throughout all time points post infection, RNA of the TBEV-FE was detected significantly more often than RNA of the other two strains in all organs studied. TBEV-FE also induced prolonged viremia, indicating distinctive kinetics in rodents in comparison to the other two subtypes. This study shows that bank voles can develop a neuroinvasive TBEV infection with persistence of viral RNA in brain, and mount an anti-TBEV IgG response. The findings also provide further evidence that bank voles can serve as sentinels for TBEV endemicity. fi
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof PLoS One
dc.rights en
dc.subject 1183 Plant biology, microbiology, virology en
dc.subject 3111 Biomedicine en
dc.title The Three Subtypes of Tick-Borne Encephalitis Virus Induce Encephalitis in a Natural Host, the Bank Vole (Myodes glareolus) en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1371/journal.pone.0081214
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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